Metabolism Antibodies 1
Anti-Hsp90 beta Antibody (CAB1087)
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- SKU:
- CAB1087
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Reactivity:
- Monkey
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-Hsp90 beta Antibody |
| Antibody SKU: | CAB1087 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat, Monkey |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human Hsp90 beta (NP_031381.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat, Monkey |
| Positive Samples: | K-562, DU145, SW620, COS-7, NIH/3T3, HeLa |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human Hsp90 beta (NP_031381.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MPEE VHHG EEEV ETFA FQAE IAQL MSLI INTF YSNK EIFL RELI SNAS DALD KIRY ESLT DPSK LDSG KELK IDII PNPQ ERTL TLVD TGIG MTKA DLIN NLGT IAKS GTKA FMEA LQAG ADIS MIGQ FGVG FYSA YLVA EKVV VITK HNDD EQYA WESS AGGS FTVR ADHG EPIG RGTK VILH LKED QTEY LEER RVKE VVKK HSQF IGYP ITLY LEKE REKE ISDD EAEE EKGE KEEE DKDD EEKP KIED VGSD EEDD SGKD KKKK TKKI KEKY IDQE ELNK TKPI WTRN PDDI TQEE |
| Gene ID: | 3326 |
| Uniprot: | P08238 |
| Cellular Location: | Cytoplasm, Melanosome |
| Calculated MW: | 83kDa |
| Observed MW: | 80kDa |
| Synonyms: | D6S182, HSP84, HSP90B, HSPC2, HSPCB, Hsp90 beta, HSP90AB1 |
| Background: | This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. |
| UniProt Protein Function: | HSP90B: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Homodimer. Interacts with p53/TP53. Forms a complex with CDK6 and Hsp90/HSP90AB1. Interacts with UNC45A. Binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer. Interacts with CHORDC1 and DNAJC7. Interacts with FKBP4. Belongs to the heat shock protein 90 family. |
| UniProt Protein Details: | Protein type:Heat shock protein; Chaperone Chromosomal Location of Human Ortholog: 6p12 Cellular Component: apical plasma membrane; basolateral plasma membrane; brush border membrane; cell surface; cytoplasm; cytosol; inclusion body; melanosome; membrane; mitochondrion; nucleoplasm; signalosome Molecular Function:ATP binding; dATP binding; double-stranded RNA binding; GTP binding; histone deacetylase binding; kinase binding; nitric-oxide synthase regulator activity; protein binding; protein kinase binding; sulfonylurea receptor binding; TPR domain binding; unfolded protein binding Biological Process: axon guidance; innate immune response; negative regulation of neuron apoptosis; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; placenta development; positive regulation of cell size; positive regulation of nitric oxide biosynthetic process; positive regulation of protein binding; positive regulation of protein import into nucleus, translocation; protein folding; regulation of protein ubiquitination; response to salt stress; response to unfolded protein; virion attachment to host cell surface receptor |
| NCBI Summary: | This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012] |
| UniProt Code: | P08238 |
| NCBI GenInfo Identifier: | 17865718 |
| NCBI Gene ID: | 3326 |
| NCBI Accession: | P08238.4 |
| UniProt Secondary Accession: | P08238,Q5T9W7, Q9NQW0, Q9NTK6, B2R5P0, |
| UniProt Related Accession: | P08238 |
| Molecular Weight: | 83,264 Da |
| NCBI Full Name: | Heat shock protein HSP 90-beta |
| NCBI Synonym Full Names: | heat shock protein 90kDa alpha family class B member 1 |
| NCBI Official Symbol: | HSP90AB1 |
| NCBI Official Synonym Symbols: | HSP84; HSPC2; HSPCB; D6S182; HSP90B |
| NCBI Protein Information: | heat shock protein HSP 90-beta |
| UniProt Protein Name: | Heat shock protein HSP 90-beta |
| UniProt Synonym Protein Names: | Heat shock 84 kDa; HSP 84; HSP84 |
| Protein Family: | Heat shock protein |
| UniProt Gene Name: | HSP90AB1 |
| UniProt Entry Name: | HS90B_HUMAN |
 | Western blot analysis of extracts of various cell lines, using HSP90AB1 antibody (CAB1087) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Western blot analysis of extracts from normal (control) and Hsp90 beta knockout (KO) HeLa cells, using Hsp90 beta antibody (CAB1087) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat lung using HSP90AB1 Antibody (CAB1087) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human colon using HSP90AB1 Antibody (CAB1087) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse kidney using HSP90AB1 Antibody (CAB1087) at dilution of 1:100 (40x lens). |
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