Cell Biology Antibodies 13
Anti-HSH2D Antibody (CAB17233)
(No reviews yet)
Write a Review
- SKU:
- CAB17233
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-HSH2D Antibody |
| Antibody SKU: | CAB17233 |
| Antibody Size: | 20uL, 50 uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 15-115 of human HSH2D (NP_001278203.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 15-115 of human HSH2D (NP_001278203.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RAQS SCCH FMVK LLDD GTFM IPGE KVAH TSLD ALVT FHQQ KPIE PRRE LLTQ PCRQ KDPA NVDY EDLF LYSN AVAE EAAC PVSA PEEA SPKP VLCH QSKE R |
| Gene ID: | 84941 |
| Uniprot: | Q96JZ2 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | HSH2D, ALX, HSH2 |
| Background: | T-cell activation requires 2 signals: recognition of antigen by the T-cell receptor (see TCR; MIM 186880) and a costimulatory signal provided primarily by CD28 (MIM 186760) in naive T cells. HSH2 is a target of both of these signaling pathways (Greene et al., 2003 [PubMed 12960172]). |
| UniProt Protein Function: | HSH2: May be a modulator of the apoptotic response through its ability to affect mitochondrial stability. Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 19p13.11 Molecular Function:protein binding |
| NCBI Summary: | T-cell activation requires 2 signals: recognition of antigen by the T-cell receptor (see TCR; MIM 186880) and a costimulatory signal provided primarily by CD28 (MIM 186760) in naive T cells. HSH2 is a target of both of these signaling pathways (Greene et al., 2003 [PubMed 12960172]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q96JZ2 |
| NCBI GenInfo Identifier: | 16877105 |
| NCBI Gene ID: | 84941 |
| NCBI Accession: | AAH16826.1 |
| UniProt Secondary Accession: | Q96JZ2,Q6ZNG7, B5ME72, |
| UniProt Related Accession: | Q96JZ2 |
| Molecular Weight: | 32,704 Da |
| NCBI Full Name: | HSH2D protein, partial |
| NCBI Synonym Full Names: | hematopoietic SH2 domain containing |
| NCBI Official Symbol: | HSH2D |
| NCBI Official Synonym Symbols: | ALX; HSH2 |
| NCBI Protein Information: | hematopoietic SH2 domain-containing protein |
| UniProt Protein Name: | Hematopoietic SH2 domain-containing protein |
| UniProt Synonym Protein Names: | Adaptor in lymphocytes of unknown function X |
| Protein Family: | Hematopoietic SH2 domain-containing protein |
| UniProt Gene Name: | HSH2D |
Related Products
Human anti-EPO antibody(anti-Erythropoietin antibody) ELISA Kit
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीक
Mouse Hematopoietic SH2 domain-containing protein (Hsh2d) ELISA Kit
Mouse Cell Signalling ELISA Kits 3
Human Anti-DSG3 antibody(anti-Desmoglein-3 antibody) ELISA Kit
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीक