Cell Biology Antibodies 13

Anti-HSH2D Antibody (CAB17233)

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SKU:
CAB17233
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-HSH2D Antibody
Antibody SKU:CAB17233
Antibody Size:20uL, 50 uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 15-115 of human HSH2D (NP_001278203.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 15-115 of human HSH2D (NP_001278203.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:RAQS SCCH FMVK LLDD GTFM IPGE KVAH TSLD ALVT FHQQ KPIE PRRE LLTQ PCRQ KDPA NVDY EDLF LYSN AVAE EAAC PVSA PEEA SPKP VLCH QSKE R
Gene ID:84941
Uniprot:Q96JZ2
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:HSH2D, ALX, HSH2
Background:T-cell activation requires 2 signals: recognition of antigen by the T-cell receptor (see TCR; MIM 186880) and a costimulatory signal provided primarily by CD28 (MIM 186760) in naive T cells. HSH2 is a target of both of these signaling pathways (Greene et al., 2003 [PubMed 12960172]).
UniProt Protein Function:HSH2: May be a modulator of the apoptotic response through its ability to affect mitochondrial stability. Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Adaptor/scaffold

Chromosomal Location of Human Ortholog: 19p13.11

Molecular Function:protein binding

NCBI Summary:T-cell activation requires 2 signals: recognition of antigen by the T-cell receptor (see TCR; MIM 186880) and a costimulatory signal provided primarily by CD28 (MIM 186760) in naive T cells. HSH2 is a target of both of these signaling pathways (Greene et al., 2003 [PubMed 12960172]).[supplied by OMIM, Mar 2008]
UniProt Code:Q96JZ2
NCBI GenInfo Identifier:16877105
NCBI Gene ID:84941
NCBI Accession:AAH16826.1
UniProt Secondary Accession:Q96JZ2,Q6ZNG7, B5ME72,
UniProt Related Accession:Q96JZ2
Molecular Weight:32,704 Da
NCBI Full Name:HSH2D protein, partial
NCBI Synonym Full Names:hematopoietic SH2 domain containing
NCBI Official Symbol:HSH2D  
NCBI Official Synonym Symbols:ALX; HSH2  
NCBI Protein Information:hematopoietic SH2 domain-containing protein
UniProt Protein Name:Hematopoietic SH2 domain-containing protein
UniProt Synonym Protein Names:Adaptor in lymphocytes of unknown function X
Protein Family:Hematopoietic SH2 domain-containing protein
UniProt Gene Name:HSH2D  
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