Metabolism Antibodies 1
Anti-HSF2 Antibody (CAB12264)
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- SKU:
- CAB12264
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-HSF2 Antibody |
| Antibody SKU: | CAB12264 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 377-536 of human HSF2 (NP_004497.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, LO2, HeLa, Mouse heart, Rat liver, Rat testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 377-536 of human HSF2 (NP_004497.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MLSG RQFS IDPD LLVD LFTS SVQM NPTD YINN TKSE NKGL ETTK NNVV QPVS EEGR KSKS KPDK QLIQ YTAF PLLA FLDG NPAS SVEQ ASTT ASSE VLSS VDKP IEVD ELLD SSLD PEPT QSKL VRLE PLTE AEAS EATL FYLC ELAP APLD SDMP LLDS |
| Gene ID: | 3298 |
| Uniprot: | Q03933 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 58kDa/60kDa |
| Observed MW: | 60kDa |
| Synonyms: | HSF2, HSF 2, HSTF 2, HSTF2 |
| Background: | The protein encoded by this gene belongs to the HSF family of transcription factors that bind specifically to the heat-shock promoter element and activate transcription. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | HSF2: DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked. Belongs to the HSF family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 6q22.31 Cellular Component: cytoplasm; nucleus Molecular Function:protein homodimerization activity; transcription coactivator activity; transcription factor activity Biological Process: transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; spermatogenesis |
| NCBI Summary: | The protein encoded by this gene belongs to the HSF family of transcription factors that bind specifically to the heat-shock promoter element and activate transcription. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] |
| UniProt Code: | Q03933 |
| NCBI GenInfo Identifier: | 462334 |
| NCBI Gene ID: | 3298 |
| NCBI Accession: | Q03933.1 |
| UniProt Secondary Accession: | Q03933,Q0VAH9, Q2M1K4, Q9H445, B4DGJ4, |
| UniProt Related Accession: | Q03933 |
| Molecular Weight: | 58,293 Da |
| NCBI Full Name: | Heat shock factor protein 2 |
| NCBI Synonym Full Names: | heat shock transcription factor 2 |
| NCBI Official Symbol: | HSF2 |
| NCBI Official Synonym Symbols: | HSF 2; HSTF 2 |
| NCBI Protein Information: | heat shock factor protein 2 |
| UniProt Protein Name: | Heat shock factor protein 2 |
| UniProt Synonym Protein Names: | Heat shock transcription factor 2; HSTF 2 |
| Protein Family: | Heat shock factor protein |
| UniProt Gene Name: | HSF2 |
| UniProt Entry Name: | HSF2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using HSF2 antibody (CAB12264) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s. |
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