Anti-HSD3B1 Antibody (CAB19266)
- SKU:
- CAB19266
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- HSD3B1
- Synonyms:
- 3BETAHSD
- Synonyms:
- HSD3B
- Synonyms:
- HSDB3
- Synonyms:
- HSDB3A
- Synonyms:
- I
- Synonyms:
- SDR11E1
- Synonyms:
- 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
- Research Area:
- Metabolism
Description
| Product Name: | HSD3B1 Rabbit mAb |
| Product Code: | CAB19266 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | HSD3B1, 3BETAHSD, HSD3B, HSDB3, HSDB3A, I, SDR11E1, 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human HSD3B1. |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A375, Mouse liver, Rat testis, Rat ovary |
| Immunogen: | Recombinant protein of human HSD3B1. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3283 |
| Uniprot: | P14060 |
| Cellular Location: | Endoplasmic reticulum membrane, Mitochondrion membrane, Single-pass membrane protein |
| Calculated MW: | 42kDa |
| Observed MW: | 42KDa |
| UniProt Protein Function: | HSD3B1: 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Efficiently catalyzes the transformation of pregnenolone to progesterone, 17-alpha-hydroxypregnenolone to 17- alpha-hydroxyprogesterone, DHEA to 4-androstenedione, dihydrotestosterone to 5-alpha-androstane-3 beta,17 beta-diol, dehydroepiandrosterone to androstenedione and 5-alpha-androstan-3 beta,17 beta-diol to 5-alpha-dihydrotestosterone. Belongs to the 3-beta-HSD family. |
| UniProt Protein Details: | Protein type:Lipid Metabolism - androgen and estrogen; EC 5.3.3.1; Membrane protein, integral; EC 1.1.1.145; Oxidoreductase; Lipid Metabolism - C21-steroid hormone; Isomerase; Mitochondrial Chromosomal Location of Human Ortholog: 1p13.1 Cellular Component: endoplasmic reticulum membrane; mitochondrial inner membrane; mitochondrial intermembrane space; smooth endoplasmic reticulum membrane Molecular Function:3-beta-hydroxy-delta5-steroid dehydrogenase activity; steroid delta-isomerase activity Biological Process: androgen biosynthetic process; estrogen biosynthetic process; glucocorticoid biosynthetic process; mineralocorticoid biosynthetic process; steroid biosynthetic process |
| NCBI Summary: | The protein encoded by this gene is an enzyme that catalyzes the oxidative conversion of delta-5-3-beta-hydroxysteroid precursors into delta-4-ketosteroids, which leads to the production of all classes of steroid hormones. The encoded protein also catalyzes the interconversion of 3-beta-hydroxy- and 3-keto-5-alpha-androstane steroids. [provided by RefSeq, Jun 2016] |
| UniProt Code: | P14060 |
| NCBI GenInfo Identifier: | 112767 |
| NCBI Gene ID: | 3283 |
| NCBI Accession: | P14060.2 |
| UniProt Secondary Accession: | P14060,Q14545, Q8IV65, A8K691, |
| UniProt Related Accession: | P14060 |
| Molecular Weight: | 42,252 Da |
| NCBI Full Name: | 3 beta-hydroxysteroid dehydrogenase/Delta 5--> |
| NCBI Synonym Full Names: | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
| NCBI Official Symbol: | HSD3B1 |
| NCBI Official Synonym Symbols: | I; HSD3B; HSDB3; HSDB3A; SDR11E1; 3BETAHSD |
| NCBI Protein Information: | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 |
| UniProt Protein Name: | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 |
| UniProt Synonym Protein Names: | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I; 3-beta-HSD I; Trophoblast antigen FDO161GIncluding the following 2 domains:3-beta-hydroxy-Delta(5)-steroid dehydrogenase (EC:1.1.1.145)Alternative name(s):3-beta-hydroxy-5-ene steroid dehydrogenase; Progesterone reductase |
| Protein Family: | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase |
| UniProt Gene Name: | HSD3B1 |
| UniProt Entry Name: | 3BHS1_HUMAN |
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