Cell Biology Antibodies 13
Anti-HSD17B7 Antibody (CAB17157)
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- SKU:
- CAB17157
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-HSD17B7 Antibody |
| Antibody SKU: | CAB17157 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 110-200 of human HSD17B7 (NP_057455.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse liver, Mouse ovary |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 110-200 of human HSD17B7 (NP_057455.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SRKV IHMF STAE GLLT QGDK ITAD GLQE VFET NVFG HFIL IREL EPLL CHSD NPSQ LIWT SSRS ARKS NFSL EDFQ HSKG KEPY SSSK YAT |
| Gene ID: | 51478 |
| Uniprot: | P56937 |
| Cellular Location: | Cell membrane, Single-pass membrane protein |
| Calculated MW: | 34kDa/37kDa/38kDa |
| Observed MW: | 38kDa |
 | Western blot - HSD17B7 Rabbit pAb (CAB17157) |
| Synonyms: | HSD17B7, PRAP, SDR37C1 |
| Background: | HSD17B7 encodes an enzyme that functions both as a 17-beta-hydroxysteroid dehydrogenase (EC 1.1.1.62) in the biosynthesis of sex steroids and as a 3-ketosteroid reductase (EC 1.1.1.270) in the biosynthesis of cholesterol (Marijanovic et al., 2003 [PubMed 12829805]). |
| UniProt Protein Function: | HSD17B7: Responsible for the reduction of the keto group on the C-3 of sterols. Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Endoplasmic reticulum; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; EC 1.1.1.62; Lipid Metabolism - steroid biosynthesis; Oxidoreductase; EC 1.1.1.270 Chromosomal Location of Human Ortholog: 1q23 Cellular Component: endoplasmic reticulum membrane Molecular Function:3-keto sterol reductase activity Biological Process: cholesterol biosynthetic process |
| NCBI Summary: | HSD17B7 encodes an enzyme that functions both as a 17-beta-hydroxysteroid dehydrogenase (EC 1.1.1.62) in the biosynthesis of sex steroids and as a 3-ketosteroid reductase (EC 1.1.1.270) in the biosynthesis of cholesterol (Marijanovic et al., 2003 [PubMed 12829805]).[supplied by OMIM, May 2010] |
| UniProt Code: | P56937 |
| NCBI GenInfo Identifier: | 8134404 |
| NCBI Gene ID: | 51478 |
| NCBI Accession: | P56937.1 |
| UniProt Secondary Accession: | P56937,Q5T246, Q7Z4V9, Q8WWS2, Q9UF00, |
| UniProt Related Accession: | P56937 |
| Molecular Weight: | 34,476 Da |
| NCBI Full Name: | 3-keto-steroid reductase |
| NCBI Synonym Full Names: | hydroxysteroid 17-beta dehydrogenase 7 |
| NCBI Official Symbol: | HSD17B7 |
| NCBI Official Synonym Symbols: | PRAP; SDR37C1 |
| NCBI Protein Information: | 3-keto-steroid reductase |
| UniProt Protein Name: | 3-keto-steroid reductase |
| UniProt Synonym Protein Names: | 17-beta-hydroxysteroid dehydrogenase 7; 17-beta-HSD 7; Estradiol 17-beta-dehydrogenase 7 (EC:1.1.1.62); Short chain dehydrogenase/reductase family 37C member 1 |
| UniProt Gene Name: | HSD17B7 |
| UniProt Entry Name: | DHB7_HUMAN |
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