Metabolism Antibodies 1
Anti-HSD17B1 Antibody (CAB10839)
(No reviews yet)
Write a Review
- SKU:
- CAB10839
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-HSD17B1 Antibody |
| Antibody SKU: | CAB10839 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-328 of human HSD17B1 (NP_000404.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, Rat ovary |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-328 of human HSD17B1 (NP_000404.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MART VVLI TGCS SGIG LHLA VRLA SDPS QSFK VYAT LRDL KTQG RLWE AARA LACP PGSL ETLQ LDVR DSKS VAAA RERV TEGR VDVL VCNA GLGL LGPL EALG EDAV ASVL DVNV VGTV RMLQ AFLP DMKR RGSG RVLV TGSV GGLM GLPF NDVY CASK FALE GLCE SLAV LLLP FGVH LSLI ECGP VHTA FMEK VLGS PEEV LDRT DIHT FHRF YQYL AHSK QVFR EAAQ NPEE VAEV FLTA LRAP KPTL RYFT TERF LPLL RMRL DDPS GSNY VTAM HREV FGDV PAKA EAGA EAGG GAGP GAED EAGR GAVG DPEL GDPP AAPQ |
| Gene ID: | 3292 |
| Uniprot: | P14061 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 34kDa |
| Observed MW: | 35kDa |
| Synonyms: | HSD17B1, 17-beta-HSD, 20-alpha-HSD, E2DH, EDH17B2, EDHB17, HSD17, SDR28C1 |
| Background: |
| UniProt Protein Function: | HSD17B1: Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH. Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
| UniProt Protein Details: | Protein type:Lipid Metabolism - androgen and estrogen; EC 1.1.1.62; Oxidoreductase Chromosomal Location of Human Ortholog: 17q11-q21 Cellular Component: nucleoplasm; nuclear membrane; cytoplasm; cytosol Molecular Function:estradiol 17-beta-dehydrogenase activity; catalytic activity; 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity Biological Process: steroid metabolic process; estrogen metabolic process; steroid biosynthetic process; estrogen biosynthetic process |
| UniProt Code: | P14061 |
| NCBI GenInfo Identifier: | 313104233 |
| NCBI Gene ID: | 3292 |
| NCBI Accession: | P14061.3 |
| UniProt Secondary Accession: | P14061,Q2M2L8, B3KXS1, |
| UniProt Related Accession: | P14061 |
| Molecular Weight: | 34,950 Da |
| NCBI Full Name: | Estradiol 17-beta-dehydrogenase 1 |
| NCBI Synonym Full Names: | hydroxysteroid (17-beta) dehydrogenase 1 |
| NCBI Official Symbol: | HSD17B1 |
| NCBI Official Synonym Symbols: | HSD17; EDHB17; EDH17B2; SDR28C1 |
| NCBI Protein Information: | estradiol 17-beta-dehydrogenase 1; E2DH; 20-alpha-HSD; 17-beta-HSD 1; estradiol 17-beta-dehydrogenase-1; 20 alpha-hydroxysteroid dehydrogenase; 17-beta-hydroxysteroid dehydrogenase type 1; placental 17-beta-hydroxysteroid dehydrogenase; hydroxysteroid (17-beta) dehydrogenase 1 isoform; short chain dehydrogenase/reductase family 28CE, member 1 |
| UniProt Protein Name: | Estradiol 17-beta-dehydrogenase 1 |
| UniProt Synonym Protein Names: | 17-beta-hydroxysteroid dehydrogenase type 1; 17-beta-HSD 1; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; E2DH; Placental 17-beta-hydroxysteroid dehydrogenase |
| Protein Family: | Estradiol 17-beta-dehydrogenase |
| UniProt Gene Name: | HSD17B1 |
| UniProt Entry Name: | DHB1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using HSD17B1 antibody (CAB10839) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
 | Immunohistochemistry of paraffin-embedded human placenta using HSD17B1 antibody (CAB10839) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse heart using HSD17B1 antibody (CAB10839) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of C6 cells using HSD17B1 Polyclonal Antibody (CAB10839) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of HeLa cells using HSD17B1 Polyclonal Antibody (CAB10839) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
View AllClose
Related Products
Anti-ERAB/HSD17B10 Antibody (CAB0959)
OverviewProduct Name:ERAB/HSD17B10 Rabbit mAbProduct Code:CAB0959Size:20uL, 50uL, 100uLSynonyms:17b-HSD10, ABAD, CAMR, DUPXp11.22, ERAB,
