Cell Biology Antibodies 17
Anti-HSC70 Interacting Protein HIP Antibody (CAB9567)
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- SKU:
- CAB9567
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-HSC70 Interacting Protein HIP Antibody |
| Antibody SKU: | CAB9567 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human HSC70 Interacting Protein HIP |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, 293T, NIH/3T3, Mouse brain, Mouse spleen |
| Immunogen: | A synthesized peptide derived from human HSC70 Interacting Protein HIP |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 6767 |
| Uniprot: | P50502 |
| Cellular Location: | |
| Calculated MW: | 47kDa |
| Observed MW: | 50KDa |
| Synonyms: | AAG2, FAM10A1, FAM10A4, HIP, HOP, HSPABP, HSPABP1, P48, PRO0786, SNC6 |
| Background: | The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that it is a candidate tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013] |
| UniProt Protein Function: | HIP: One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins. Homotetramer. Interacts with HSC70 as well as DNAJ homologs and HSP90. Interacts (via the C-terminus 303- 319 AA) with GRK5. Belongs to the FAM10 family. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 22q13.2 Cellular Component: protein complex; cytoplasm; cytosol Molecular Function:protein binding, bridging; identical protein binding; protein domain specific binding; protein binding; chaperone binding; unfolded protein binding; protein complex binding; dATP binding; Hsp70 protein binding Biological Process: protein folding; protein homooligomerization |
| NCBI Summary: | The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that it is a candidate tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013] |
| UniProt Code: | P50502 |
| NCBI GenInfo Identifier: | 6686278 |
| NCBI Gene ID: | 6767 |
| NCBI Accession: | P50502.2 |
| UniProt Secondary Accession: | P50502,O14999, Q2TU77, |
| UniProt Related Accession: | P50502 |
| Molecular Weight: | 41,332 Da |
| NCBI Full Name: | Hsc70-interacting protein |
| NCBI Synonym Full Names: | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) |
| NCBI Official Symbol: | ST13 |
| NCBI Official Synonym Symbols: | HIP; HOP; P48; AAG2; SNC6; HSPABP; FAM10A1; FAM10A4; HSPABP1; PRO0786 |
| NCBI Protein Information: | hsc70-interacting protein; Hsp70-interacting protein; aging-associated protein 2; putative tumor suppressor ST13; renal carcinoma antigen NY-REN-33; heat shock 70kD protein binding protein; suppression of tumorigenicity 13 protein; progesterone receptor-associated p48 protein |
| UniProt Protein Name: | Hsc70-interacting protein |
| UniProt Synonym Protein Names: | Aging-associated protein 2; Progesterone receptor-associated p48 protein; Protein FAM10A1; Putative tumor suppressor ST13; Renal carcinoma antigen NY-REN-33; Suppression of tumorigenicity 13 protein |
| Protein Family: | Hsc70-interacting protein |
| UniProt Gene Name: | ST13 |
| UniProt Entry Name: | F10A1_HUMAN |
 | Western blot - HSC70 Interacting Protein HIP Rabbit mAb (CAB9567) |
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