Anti-HRH3 Antibody (CAB3500)

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SKU:
CAB3500
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
GPCR97
Synonyms:
HH3R
Research Area:
Neuroscience

Description

Product Name:HRH3 Rabbit mAb
Product Code:CAB3500
Size:20uL, 50uL, 100uL
Synonyms:GPCR97, HH3R
Applications:WB, IP
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human HRH3
Applications:WB, IP
Recommended Dilutions:WB 1:500 - 1:2000 IP 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse testis, Mouse brain, Mouse spleen, Rat testis, Rat brain, Rat spleen, Raji, SH-SY5Y, U-251MG
Immunogen:A synthesized peptide derived from human HRH3
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:11255
Uniprot:Q9Y5N1
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:45kDa
Observed MW:45kDa
UniProt Protein Function:H3R: The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 niether modified adenylate cyclase activity nor induced intracellular calcium mobilization. Belongs to the G-protein coupled receptor 1 family. 7 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: 20q13.33

Cellular Component: neuron projection; integral to plasma membrane; plasma membrane; myelin sheath

Molecular Function:drug binding; histamine receptor activity

Biological Process: negative regulation of glutamate secretion; eating behavior; neurotransmitter secretion; drinking behavior; negative regulation of gamma-aminobutyric acid secretion; negative regulation of adenylate cyclase activity; learning; regulation of norepinephrine secretion; response to organic cyclic substance; memory; G-protein signaling, coupled to cyclic nucleotide second messenger; negative regulation of serotonin secretion; elevation of cytosolic calcium ion concentration; brain development; negative regulation of blood pressure; positive regulation of epithelial cell proliferation

NCBI Summary:Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smooth muscles and innervates the blood vessels and the heart in cardiovascular system. [provided by RefSeq, Jul 2008]
UniProt Code:Q9Y5N1
NCBI GenInfo Identifier:17367264
NCBI Gene ID:11255
NCBI Accession:Q9Y5N1.2
UniProt Secondary Accession:Q9Y5N1,Q4QRI7, Q9GZX2, Q9H4K8,
UniProt Related Accession:Q9Y5N1
Molecular Weight:45,607 Da
NCBI Full Name:Histamine H3 receptor
NCBI Synonym Full Names:histamine receptor H3
NCBI Official Symbol:HRH3  
NCBI Official Synonym Symbols:HH3R; GPCR97  
NCBI Protein Information:histamine H3 receptor; G protein-coupled receptor 97; G-protein coupled receptor 97; H3R
UniProt Protein Name:Histamine H3 receptor
UniProt Synonym Protein Names:G-protein coupled receptor 97
Protein Family:Histamine H3 receptor
UniProt Gene Name:HRH3  
UniProt Entry Name:HRH3_HUMAN
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