Immunology Antibodies 2
Anti-HPX Antibody (CAB5603)
- SKU:
- CAB5603
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-HPX Antibody |
| Antibody SKU: | CAB5603 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-245 of human HPX (NP_000604.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:10 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HL-60, HepG2, BT-474, Mouse liver, Mouse pancreas |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-245 of human HPX (NP_000604.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TPLP PTSA HGNV AEGE TKPD PDVT ERCS DGWS FDAT TLDD NGTM LFFK GEFV WKSH KWDR ELIS ERWK NFPS PVDA AFRQ GHNS VFLI KGDK VWVY PPEK KEKG YPKL LQDE FPGI PSPL DAAV ECHR GECQ AEGV LFFQ GDRE WFWD LATG TMKE RSWP AVGN CSSA LRWL GRYY CFQG NQFL RFDP VRGE VPPR YPRD VRDY FMPC PGRG HGHR NGTG HG |
| Gene ID: | 3263 |
| Uniprot: | P02790 |
| Cellular Location: | Secreted |
| Calculated MW: | 51kDa |
| Observed MW: | 68kDa |
| Synonyms: | HPX, HX, hemopexin |
| Background: | This gene encodes a plasma glycoprotein that binds heme with high affinity. The encoded protein is an acute phase protein that transports heme from the plasma to the liver and may be involved in protecting cells from oxidative stress. |
| UniProt Protein Function: | HPX: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. Belongs to the hemopexin family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 11p15.5-p15.4 Cellular Component: extracellular space; extracellular region Molecular Function:protein binding; metal ion binding; heme transporter activity Biological Process: positive regulation of humoral immune response mediated by circulating immunoglobulin; receptor-mediated endocytosis; positive regulation of immunoglobulin production; heme transport; positive regulation of tyrosine phosphorylation of Stat1 protein; viral reproduction; hemoglobin metabolic process; cellular iron ion homeostasis; heme metabolic process |
| NCBI Summary: | This gene encodes a plasma glycoprotein that binds heme with high affinity. The encoded protein is an acute phase protein that transports heme from the plasma to the liver and may be involved in protecting cells from oxidative stress. [provided by RefSeq, Apr 2009] |
| UniProt Code: | P02790 |
| NCBI GenInfo Identifier: | 11321561 |
| NCBI Gene ID: | 3263 |
| NCBI Accession: | NP_000604 |
| UniProt Secondary Accession: | P02790,B2R957, |
| UniProt Related Accession: | P02790 |
| Molecular Weight: | 51.7 kDa (462aa) |
| NCBI Full Name: | hemopexin |
| NCBI Synonym Full Names: | hemopexin |
| NCBI Official Symbol: | HPX |
| NCBI Official Synonym Symbols: | HX |
| NCBI Protein Information: | hemopexin |
| UniProt Protein Name: | Hemopexin |
| UniProt Synonym Protein Names: | Beta-1B-glycoprotein |
| Protein Family: | Hemopexin |
| UniProt Gene Name: | HPX |
| UniProt Entry Name: | HEMO_HUMAN |
 | Western blot analysis of extracts of various cell lines, using HPX antibody (CAB5603) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat testis using HPX antibody (CAB5603) at dilution of 1:100 (20x lens). |
 | Immunohistochemistry of paraffin-embedded mouse testis using HPX antibody (CAB5603) at dilution of 1:100 (20x lens). |
 | Immunofluorescence analysis of U2OS cells using HPX antibody (CAB5603). Blue: DAPI for nuclear staining. |
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