Name: Anti-HPRT Antibody (CAB8783)
Brand: Metabolism Antibodies 3
SKU: CAB8783
Availability: OutOfStock

Antibody Name:	Anti-HPRT Antibody
Antibody SKU:	CAB8783
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	A synthesized peptide derived from human HPRT

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:	HeLa, 293T, NIH/3T3, Mouse brain, Mouse heart, Rat heart, Rat thymus

Immunogen:	A synthesized peptide derived from human HPRT
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	3251
Uniprot:	P00492
Cellular Location:
Calculated MW:	25kDa
Observed MW:	25KDa

Synonyms:

HGPRT, HPRT

Background:

The protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway. Mutations in this gene result in Lesch-Nyhan syndrome or gout.[provided by RefSeq, Jun 2009]

UniProt Protein Function:	HPRT1: Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5- phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway. Defects in HPRT1 are the cause of Lesch-Nyhan syndrome (LNS). LNS is characterized by complete lack of enzymatic activity that results in hyperuricemia, choreoathetosis, mental retardation, and compulsive self-mutilation. Defects in HPRT1 are the cause of gout HPRT-related (GOUT-HPRT); also known as HPRT-related gout or Kelley-Seegmiller syndrome. Gout is characterized by partial enzyme activity and hyperuricemia. Belongs to the purine/pyrimidine phosphoribosyltransferase family.
UniProt Protein Details:	Protein type:EC 2.4.2.8; Xenobiotic Metabolism - drug metabolism - other enzymes; Transferase; Nucleotide Metabolism - purine; Cell development/differentiation Chromosomal Location of Human Ortholog: Xq26.1 Cellular Component: cytoplasm; cytosol Molecular Function:protein binding; protein homodimerization activity; hypoxanthine phosphoribosyltransferase activity; magnesium ion binding; nucleotide binding Biological Process: grooming behavior; lymphocyte proliferation; hypoxanthine metabolic process; IMP salvage; striatum development; nucleobase, nucleoside and nucleotide metabolic process; GMP salvage; dendrite morphogenesis; cytolysis; response to amphetamine; locomotory behavior; adenine salvage; purine nucleotide biosynthetic process; dopamine metabolic process; purine base metabolic process; purine salvage; cerebral cortex neuron differentiation; protein homotetramerization; positive regulation of dopamine metabolic process; GMP catabolic process; IMP metabolic process; hypoxanthine salvage; purine ribonucleoside salvage; central nervous system neuron development; guanine salvage Disease: Kelley-seegmiller Syndrome; Lesch-nyhan Syndrome
NCBI Summary:	The protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway. Mutations in this gene result in Lesch-Nyhan syndrome or gout.[provided by RefSeq, Jun 2009]
UniProt Code:	P00492
NCBI GenInfo Identifier:	123497
NCBI Gene ID:	3251
NCBI Accession:	P00492.2
UniProt Secondary Accession:	P00492,A6NHF0, B2R8M9,
UniProt Related Accession:	P00492
Molecular Weight:	218
NCBI Full Name:	Hypoxanthine-guanine phosphoribosyltransferase
NCBI Synonym Full Names:	hypoxanthine phosphoribosyltransferase 1
NCBI Official Symbol:	HPRT1
NCBI Official Synonym Symbols:	HPRT; HGPRT
NCBI Protein Information:	hypoxanthine-guanine phosphoribosyltransferase; HGPRTase
UniProt Protein Name:	Hypoxanthine-guanine phosphoribosyltransferase
Protein Family:	Hypoxanthine-guanine phosphoribosyltransferase
UniProt Gene Name:	HPRT1
UniProt Entry Name:	HPRT_HUMAN