Cell Biology Antibodies 12
Anti-HPR Antibody (CAB9898)
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- SKU:
- CAB9898
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IHC
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-HPR Antibody |
| Antibody SKU: | CAB9898 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-348 of human HPR (NP_066275.3). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HepG2, HL-60, BT-474, K-562 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-348 of human HPR (NP_066275.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LYSG NDVT DISD DRFP KPPE IANG YVEH LFRY QCKN YYRL RTEG DGVY TLND KKQW INKA VGDK LPEC EAVC GKPK NPAN PVQR ILGG HLDA KGSF PWQA KMVS HHNL TTGA TLIN EQWL LTTA KNLF LNHS ENAT AKDI APTL TLYV GKKQ LVEI EKVV LHPN YHQV DIGL IKLK QKVL VNER VMPI CLPS KNYA EVGR VGYV SGWG QSDN FKLT DHLK YVML PVAD QYDC ITHY EGST CPKW KAPK SPVG VQPI LNEH TFCV GMSK YQED TCYG DAGS AFAV HDLE EDTW YAAG ILSF DKSC AVAE YGVY VKVT SIQH WVQK TIAE N |
| Gene ID: | 3250 |
| Uniprot: | P00739 |
| Cellular Location: | Secreted |
| Calculated MW: | 39kDa/43kDa |
| Observed MW: | 39kDa |
| Synonyms: | HPR, A-259H10.2, HP |
| Background: | This gene encodes a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer. |
| UniProt Protein Function: | HPR: a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer. [provided by RefSeq, Oct 2011] |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 16q22.1 Cellular Component: extracellular region Biological Process: positive regulation of defense response to virus by host; receptor-mediated endocytosis |
| NCBI Summary: | This gene encodes a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer. [provided by RefSeq, Oct 2011] |
| UniProt Code: | P00739 |
| NCBI GenInfo Identifier: | 262527547 |
| NCBI Gene ID: | 3250 |
| NCBI Accession: | P00739.2 |
| UniProt Secondary Accession: | P00739,Q7LE20, Q92658, Q92659, Q9ULB0, |
| UniProt Related Accession: | P00739 |
| Molecular Weight: | 43,078 Da |
| NCBI Full Name: | Haptoglobin-related protein |
| NCBI Synonym Full Names: | haptoglobin-related protein |
| NCBI Official Symbol: | HPR |
| NCBI Official Synonym Symbols: | HP; A-259H10.2 |
| NCBI Protein Information: | haptoglobin-related protein |
| UniProt Protein Name: | Haptoglobin-related protein |
| Protein Family: | HPr-like protein |
| UniProt Gene Name: | HPR |
| UniProt Entry Name: | HPTR_HUMAN |
 | Western blot analysis of extracts of various cell lines, using HPR antibody (CAB9898) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
 | Immunohistochemistry of paraffin-embedded mouse lung using HPR antibody (CAB9898) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human prostate using HPR antibody (CAB9898) at dilution of 1:100 (40x lens). |
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