Anti-HPN Antibody (CAB6620)
- SKU:
- CAB6620
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- HPN
- Synonyms:
- TMPRSS1
- Synonyms:
- hepsin
Description
| Product Name: | HPN Rabbit pAb |
| Product Code: | CAB6620 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | HPN, TMPRSS1, hepsin |
| Applications: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 45-170 of human HPN (NP_002142.1). |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 45-170 of human HPN (NP_002142.1). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RSDQ EPLY PVQV SSAD ARLM VFDK TEGT WRLL CSSR SNAR VAGL SCEE MGFL RALT HSEL DVRT AGAN GTSG FFCV DEGR LPHT QRLL EVIS VCDC PRGR FLAA ICQD CGRR KLPV DRIV GGRD TS |
| Gene ID: | 3249 |
| Uniprot: | P05981 |
| Cellular Location: | Membrane, Single-pass type II membrane protein |
| Calculated MW: | 45kDa |
| Observed MW: | Refer to figures |
| UniProt Protein Function: | HPN: Plays an essential role in cell growth and maintenance of cell morphology. Belongs to the peptidase S1 family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; EC 3.4.21.106; Protease Chromosomal Location of Human Ortholog: 19q13.12 Cellular Component: endoplasmic reticulum membrane; nuclear membrane; cell surface; cell soma; integral to plasma membrane; plasma membrane; integral to membrane; intercellular junction Molecular Function:peptidase activity; calcium-activated potassium channel activity; protein binding; serine-type peptidase activity; serine-type endopeptidase activity Biological Process: regulation of cell shape; cholesterol homeostasis; detection of mechanical stimulus involved in sensory perception of sound; proteolysis; positive regulation of cell growth; negative regulation of epithelial cell proliferation; negative regulation of apoptosis |
| NCBI Summary: | This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate cancer. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013] |
| UniProt Code: | P05981 |
| NCBI GenInfo Identifier: | 123057 |
| NCBI Gene ID: | 3249 |
| NCBI Accession: | P05981.1 |
| UniProt Related Accession: | P05981 |
| Molecular Weight: | 45 kDa |
| NCBI Full Name: | Serine protease hepsin |
| NCBI Synonym Full Names: | hepsin |
| NCBI Official Symbol: | HPN |
| NCBI Official Synonym Symbols: | TMPRSS1 |
| NCBI Protein Information: | serine protease hepsin |
| UniProt Protein Name: | Serine protease hepsin |
| UniProt Synonym Protein Names: | Transmembrane protease serine 1Cleaved into the following 2 chains:Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain |
| Protein Family: | Histidine-rich metal-binding polypeptide |
| UniProt Gene Name: | HPN |
| UniProt Entry Name: | HEPS_HUMAN |
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