Cell Biology Antibodies 17

Anti-HP1 gamma Antibody (CAB4283)

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SKU:
CAB4283

Description

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Antibody Name:Anti-HP1 gamma Antibody
Antibody SKU:CAB4283
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human HP1 gamma
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, SH-SY5Y, Mouse spleen, Mouse thymus, Rat brain
Immunogen:A synthesized peptide derived from human HP1 gamma
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:11335
Uniprot:Q13185
Cellular Location:
Calculated MW:24kDa
Observed MW:22KDa
Synonyms:HECH, HP1-GAMMA, HP1Hs-gamma
Background:At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[provided by RefSeq, Mar 2011]
UniProt Protein Function:CBX3: Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Binds directly to CHAF1A. Interacts with histone H3 methylated at 'Lys-9'. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Interacts with LBR, INCENP, TRIM28/TIF1B, SUV420H1, SUV420H2 and SP100. Interacts with TIF1A. Interacts with MIS12 and DSN1. Can interact directly with CBX5 via the chromoshadow domain. Interacts with POGZ. Interacts with CHAMP1. Interacts with ASXL1.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 7p15.2

Cellular Component: chromatin; chromocenter; chromosome, pericentric region; nuclear chromosome, telomeric region; nuclear envelope; nuclear heterochromatin; nuclear inner membrane; nucleus; spindle

Molecular Function:enzyme binding; identical protein binding; protein binding; protein domain specific binding

Biological Process: chromatin remodeling; negative regulation of transcription, DNA-dependent; rhythmic process; transcription, DNA-dependent

NCBI Summary:At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[provided by RefSeq, Mar 2011]
UniProt Code:Q13185
NCBI GenInfo Identifier:116241284
NCBI Gene ID:11335
NCBI Accession:Q13185.4
UniProt Secondary Accession:Q13185,Q96CD7, Q99409, Q9BVS3, Q9P0Z6,
UniProt Related Accession:Q13185
Molecular Weight:20,811 Da
NCBI Full Name:Chromobox protein homolog 3
NCBI Synonym Full Names:chromobox 3
NCBI Official Symbol:CBX3  
NCBI Official Synonym Symbols:HECH; HP1-GAMMA; HP1Hs-gamma  
NCBI Protein Information:chromobox protein homolog 3
UniProt Protein Name:Chromobox protein homolog 3
UniProt Synonym Protein Names:HECH; Heterochromatin protein 1 homolog gamma; HP1 gamma; Modifier 2 protein
Protein Family:Chromobox protein
UniProt Gene Name:CBX3  
UniProt Entry Name:CBX3_HUMAN
Anti-HP1 gamma Antibody (CAB4283)Western blot - HP1 gamma Rabbit mAb (CAB4283)
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Additional Information

Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
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