Immunology Antibodies 1

Anti-HP Antibody (CAB14186)

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SKU:
CAB14186
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-HP Antibody
Antibody SKU:CAB14186
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 123-347 of human HP (NP_001119574.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 123-347 of human HP (NP_001119574.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:HHNL TTGA TLIN EQWL LTTA KNLF LNHS ENAT AKDI APTL TLYV GKKQ LVEI EKVV LHPN YSQV DIGL IKLK QKVS VNER VMPI CLPS KDYA EVGR VGYV SGWG RNAN FKFT DHLK YVML PVAD QDQC IRHY EGST VPEK KTPK SPVG VQPI LNEH TFCA GMSK YQED TCYG DAGS AFAV HDLE EDTW YATG ILSF DKSC AVAE YGVY VKVT SIQD WVQK TIAE N
Gene ID:3240
Uniprot:P00738
Cellular Location:Secreted
Calculated MW:38kDa/45kDa
Observed MW:Refer to figures
Synonyms:HP, BP, HP2ALPHA2, HPA1S
Background:This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:HP: Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes. Defects in HP are the cause of anhaptoglobinemia (AHP). AHP is a condition characterized by the absence of the serum glycoprotein haptoglobin. Serum levels of haptoglobin vary among normal persons: levels are low in the neonatal period and in the elderly, differ by population, and can be influenced by environmental factors, such as infection. Secondary hypohaptoglobinemia can occur as a consequence of hemolysis, during which haptoglobin binds to free hemoglobin. Belongs to the peptidase S1 family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 16q22.2

Cellular Component: extracellular space; extracellular region

Molecular Function:antioxidant activity; protein binding; hemoglobin binding; catalytic activity

Biological Process: receptor-mediated endocytosis; response to hydrogen peroxide; immune system process; metabolic process; defense response to bacterium; negative regulation of oxidoreductase activity; acute-phase response; defense response

Disease: Anhaptoglobinemia

NCBI Summary:This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]
UniProt Code:P00738
NCBI GenInfo Identifier:123508
NCBI Gene ID:3240
NCBI Accession:P00738.1
UniProt Secondary Accession:P00738,P00737, Q0VAC4, Q0VAC5, Q2PP15, Q3B7J0, Q6LBY9 Q9UC67, B0AZL5,
UniProt Related Accession:P00738
Molecular Weight:
NCBI Full Name:Haptoglobin
NCBI Synonym Full Names:haptoglobin
NCBI Official Symbol:HP  
NCBI Official Synonym Symbols:BP; HPA1S; HP2ALPHA2  
NCBI Protein Information:haptoglobin; zonulin; binding peptide; haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; haptoglobin, beta polypeptide; haptoglobin, alpha polypeptide
UniProt Protein Name:Haptoglobin
UniProt Synonym Protein Names:ZonulinCleaved into the following 2 chains:Haptoglobin alpha chain; Haptoglobin beta chain
Protein Family:Haptoglobin
UniProt Gene Name:HP  
UniProt Entry Name:HPT_HUMAN
Anti-HP Antibody (CAB14186)Immunofluorescence analysis of HeLa cells using HP antibody (CAB14186). Blue: DAPI for nuclear staining.
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