Epigenetics & Nuclear Signaling Antibodies 1

Anti-HOXD12 Antibody (CAB12870)

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SKU:
CAB12870
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-HOXD12 Antibody
Antibody SKU:CAB12870
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human HOXD12 (NP_067016.3).
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:A-549, NIH/3T3, Rat lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human HOXD12 (NP_067016.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MCER SLYR AGYV GSLL NLQS PDSF YFSN LRPN GGQL AALP PISY PRGA LPWA ATPA SCAP AQPA GATA FGGF SQPY LAGS GPLG LQPP TAKD GPEE QAKF YAPE AAAG PEER GRTR PSFA PESS LAPA VAAL KAAK YDYA GVGR ATPG STTL LQGA PCAP GFKD DTKG PLNL NMTV QAAG VASC LRPS LP
Gene ID:3238
Uniprot:P35452
Cellular Location:Nucleus
Calculated MW:22kDa/29kDa
Observed MW:33-35kDa
Synonyms:HOXD12, HOX4H
Background:This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The exact role of this gene has not been determined.
UniProt Protein Function:HOXD12: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.
UniProt Protein Details:

Protein type:DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: transcription factor complex; nucleus

Molecular Function:sequence-specific DNA binding

Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; embryonic digit morphogenesis; pattern specification process; skeletal development

UniProt Code:P35452
NCBI GenInfo Identifier:194353946
NCBI Gene ID:
NCBI Accession:NP_067016.3
Molecular Weight:~ 30kDa
NCBI Full Name:homeobox protein Hox-D12
UniProt Protein Name:Homeobox protein Hox-D12
UniProt Synonym Protein Names:Homeobox protein Hox-4H
Protein Family:Homeobox protein
UniProt Gene Name:HOXD12  
UniProt Entry Name:HXD12_HUMAN
Anti-HOXD12 Antibody (CAB12870)Western blot analysis of extracts of various cell lines, using HOXD12 antibody (CAB12870) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
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