Epigenetics & Nuclear Signaling Antibodies 3

Anti-HOXC8 Antibody (CAB2975)

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SKU:
CAB2975
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-HOXC8 Antibody
Antibody SKU:CAB2975
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide of human HOXC8
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:U-251MG
Immunogen:A synthetic peptide of human HOXC8
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3224
Uniprot:P31273
Cellular Location:Nucleus
Calculated MW:27kDa
Observed MW:28kDa
Synonyms:HOXC8, HOX3, HOX3A
Background:This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in chondrodysplasias or other cartilage disorders.
UniProt Protein Function:HOXC8: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Antp homeobox family.
UniProt Protein Details:

Protein type:DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 12q13.3

Cellular Component: microtubule cytoskeleton; nucleoplasm

Molecular Function:sequence-specific DNA binding; transcription factor activity

Biological Process: neuron differentiation; anterior/posterior pattern formation; transcription, DNA-dependent; skeletal morphogenesis; negative regulation of transcription from RNA polymerase II promoter

NCBI Summary:This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in chondrodysplasias or other cartilage disorders. [provided by RefSeq, Jul 2008]
UniProt Code:P31273
NCBI GenInfo Identifier:13124745
NCBI Gene ID:3224
NCBI Accession:P31273.2
UniProt Related Accession:P31273
Molecular Weight:
NCBI Full Name:Homeobox protein Hox-C8
NCBI Synonym Full Names:homeobox C8
NCBI Official Symbol:HOXC8  
NCBI Official Synonym Symbols:HOX3; HOX3A  
NCBI Protein Information:homeobox protein Hox-C8
UniProt Protein Name:Homeobox protein Hox-C8
UniProt Synonym Protein Names:Homeobox protein Hox-3A
UniProt Gene Name:HOXC8  
UniProt Entry Name:HXC8_HUMAN
Anti-HOXC8 Antibody (CAB2975)Western blot analysis of extracts of U-251MG cells, using HOXC8 antibody (CAB2975). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
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