Name: Anti-HOXC8 Antibody (CAB15066)
Brand: Epigenetics & Nuclear Signaling Antibodies 2
SKU: CAB15066
Availability: OutOfStock

Antibody Name:	Anti-HOXC8 Antibody
Antibody SKU:	CAB15066
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human HOXC8 (NP_073149.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Mouse, Rat
Positive Samples:	mouse spinal cord, mouse kidney, mouse liver

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human HOXC8 (NP_073149.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MSSY FVNP LFSK YKAG ESLE PAYY DCRF PQSV GRSH ALVY GPGG SAPG FQHA SHHV QDFF HHGT SGIS NSGY QQNP CSLS CHGD ASKF YGYE ALPR QSLY GAQQ EASV VQYP DCKS SANT NSSE GQGH LNQN SSPS LMFP WMRP HAPG RR
Gene ID:	3224
Uniprot:	P31273
Cellular Location:	Nucleus
Calculated MW:	27kDa
Observed MW:	38kDa

Synonyms:

HOXC8, HOX3, HOX3A

Background:

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in chondrodysplasias or other cartilage disorders.

UniProt Protein Function:	HOXC8: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Antp homeobox family.
UniProt Protein Details:	Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 12q13.3 Cellular Component: microtubule cytoskeleton; nucleoplasm Molecular Function:sequence-specific DNA binding; transcription factor activity Biological Process: neuron differentiation; anterior/posterior pattern formation; transcription, DNA-dependent; skeletal morphogenesis; negative regulation of transcription from RNA polymerase II promoter
NCBI Summary:	This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in chondrodysplasias or other cartilage disorders. [provided by RefSeq, Jul 2008]
UniProt Code:	P31273
NCBI GenInfo Identifier:	13124745
NCBI Gene ID:	3224
NCBI Accession:	P31273.2
UniProt Related Accession:	P31273
Molecular Weight:
NCBI Full Name:	Homeobox protein Hox-C8
NCBI Synonym Full Names:	homeobox C8
NCBI Official Symbol:	HOXC8
NCBI Official Synonym Symbols:	HOX3; HOX3A
NCBI Protein Information:	homeobox protein Hox-C8
UniProt Protein Name:	Homeobox protein Hox-C8
UniProt Synonym Protein Names:	Homeobox protein Hox-3A
UniProt Gene Name:	HOXC8
UniProt Entry Name:	HXC8_HUMAN

Western blot analysis of extracts of various cell lines, using HOXC8 antibody (CAB15066) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.

Antibodies

Anti-HOXC8 Antibody (CAB2975)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)