Epigenetics & Nuclear Signaling Antibodies 2

Anti-HOXC11 Antibody (CAB14742)

(No reviews yet) Write a Review
SKU:
CAB14742
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-HOXC11 Antibody
Antibody SKU:CAB14742
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human HOXC11 (NP_055027.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HeLa, 293T
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human HOXC11 (NP_055027.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MFNS VNLG NFCS PSRK ERGA DFGE RGSC ASNL YLPS CTYY MPEF STVS SFLP QAPS RQIS YPYS AQVP PVRE VSYG LEPS GKWH HRNS YSSC YAAA DELM HREC LPPS TVTE ILMK NEGS YGGH HHPS APHA TPAG FYSS VNKN SVLP QAFD RFFD NAYC GGGD PPAE PPCS GKGE AKGE PEAP PASG LASR AEAG AEAE AEEE NTNP SSSG SAHS VAKE PAKG AAPN AP
Gene ID:3227
Uniprot:O43248
Cellular Location:Nucleus
Calculated MW:33kDa
Observed MW:36kDa
Synonyms:HOXC11, HOX3H
Background:This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene binds to a promoter element of the lactase-phlorizin hydrolase. It also may play a role in early intestinal development. An alternatively spliced variant encoding a shorter isoform has been described but its full-length nature has not been determined.
UniProt Protein Function:HOXC11: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to a promoter element of the lactase-phlorizin hydrolase gene. Belongs to the Abd-B homeobox family.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 12q13.3

Cellular Component: nucleoplasm; cytoplasm

Biological Process: anterior/posterior pattern formation; transcription, DNA-dependent; induction of an organ; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; metanephros development; proximal/distal pattern formation; endoderm development

NCBI Summary:This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene binds to a promoter element of the lactase-phlorizin hydrolase. It also may play a role in early intestinal development. An alternatively spliced variant encoding a shorter isoform has been described but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]
UniProt Code:O43248
NCBI GenInfo Identifier:7657166
NCBI Gene ID:3227
NCBI Accession:NP_055027.1
UniProt Related Accession:O43248
Molecular Weight:
NCBI Full Name:homeobox protein Hox-C11
NCBI Synonym Full Names:homeobox C11
NCBI Official Symbol:HOXC11  
NCBI Official Synonym Symbols:HOX3H  
NCBI Protein Information:homeobox protein Hox-C11
UniProt Protein Name:Homeobox protein Hox-C11
UniProt Synonym Protein Names:Homeobox protein Hox-3H
UniProt Gene Name:HOXC11  
UniProt Entry Name:HXC11_HUMAN
Anti-HOXC11 Antibody (CAB14742)Western blot analysis of extracts of various cell lines, using HOXC11 antibody (CAB14742) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 5min.
View AllClose

0 Reviews

View AllClose

Related Products