Epigenetics & Nuclear Signaling Antibodies 4
Anti-HOXB5 Antibody (CAB8123)
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- SKU:
- CAB8123
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IF
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | HOXB5 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8123 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-170 of human HOXB5 (NP_002138.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: | HT-29, SKOV3 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-170 of human HOXB5 (NP_002138.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSSY FVNS FSGR YPNG PDYQ LLNY GSGS SLSG SYRD PAAM HTGS YGYN YNGM DLSV NRSS ASSS HFGA VGES SRAF PAPA QEPR FRQA ASSC SLSS PESL PCTN GDSH GAKP SASS PSDQ ATSA SSSA NFTE IDEA SASS EPEE AASQ LSSP SLAR AQPE PMAT STAA PE |
| Gene ID: | 3215 |
| Uniprot: | P09067 |
| Cellular Location: | Nucleus |
| Calculated MW: | 29kDa |
| Observed MW: | 29kDa |
| Synonyms: | HOXB5, HHO.C10, HOX2, HOX2A, HU-1, Hox2.1 |
| Background: | This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue. |
| UniProt Protein Function: | HOXB5: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Antp homeobox family. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 17q21.3 Molecular Function:protein binding Biological Process: anatomical structure morphogenesis |
| NCBI Summary: | This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P09067 |
| NCBI GenInfo Identifier: | 400000 |
| NCBI Gene ID: | 3215 |
| NCBI Accession: | P09067.3 |
| UniProt Secondary Accession: | P09067,P09069, Q17RP4, B2RC69, |
| UniProt Related Accession: | P09067 |
| Molecular Weight: | 29,434 Da |
| NCBI Full Name: | Homeobox protein Hox-B5 |
| NCBI Synonym Full Names: | homeobox B5 |
| NCBI Official Symbol: | HOXB5 |
| NCBI Official Synonym Symbols: | HOX2; HU-1; HOX2A; Hox2.1; HHO.C10 |
| NCBI Protein Information: | homeobox protein Hox-B5 |
| UniProt Protein Name: | Homeobox protein Hox-B5 |
| UniProt Synonym Protein Names: | Homeobox protein HHO.C10; Homeobox protein Hox-2A; Homeobox protein Hu-1 |
| Protein Family: | Homeobox protein |
| UniProt Gene Name: | HOXB5 |
| UniProt Entry Name: | HXB5_HUMAN |
 | Western blot analysis of extracts of various cell lines, using HOXB5 antibody (CAB8123) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
 | Immunofluorescence analysis of U2OS cells using HOXB5 antibody (CAB8123) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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