Epigenetics & Nuclear Signaling Antibodies 2

Anti-HOXB13 Antibody (CAB15779)

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SKU:
CAB15779
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-HOXB13 Antibody
Antibody SKU:CAB15779
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 50-150 of human HOXB13 (NP_006352.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:DU145, HeLa, HT-29, Mouse small intestine, Rat small intestine
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 50-150 of human HOXB13 (NP_006352.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:PLDL PGSA EPPK QCHP CPGV PQGT SPAP VPYG YFGG GYYS CRVS RSSL KPCA QAAT LAAY PAET PTAG EEYP SRPT EFAF YPGY PGTY QPMA SYLD VSVV Q
Gene ID:10481
Uniprot:Q92826
Cellular Location:Nucleus
Calculated MW:30kDa
Observed MW:27kDa
Synonyms:HOXB13, PSGD
Background:This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region.
UniProt Protein Function:HOXB13: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.
UniProt Protein Details:

Protein type:Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: nucleoplasm

Biological Process: angiogenesis; epidermis development; response to wounding

NCBI Summary:This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region. [provided by RefSeq, Jul 2008]
UniProt Code:Q92826
NCBI GenInfo Identifier:50403792
NCBI Gene ID:10481
NCBI Accession:Q92826.2
UniProt Secondary Accession:Q92826,Q96QM4, Q99810, B2R878,
UniProt Related Accession:Q92826
Molecular Weight:30,676 Da
NCBI Full Name:Homeobox protein Hox-B13
NCBI Synonym Full Names:homeobox B13
NCBI Official Symbol:HOXB13  
NCBI Official Synonym Symbols:PSGD  
NCBI Protein Information:homeobox protein Hox-B13
UniProt Protein Name:Homeobox protein Hox-B13
Protein Family:Homeobox protein
UniProt Gene Name:HOXB13  
UniProt Entry Name:HXB13_HUMAN
Anti-HOXB13 Antibody (CAB15779)Western blot analysis of extracts of various cell lines, using HOXB13 antibody (CAB15779) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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