Anti-HOXA9 Antibody (CAB19257)

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SKU:
CAB19257
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
HOXA9
Synonyms:
ABD-B
Synonyms:
HOX1
Synonyms:
HOX1.7
Synonyms:
HOX1G
Synonyms:
homeobox A9
Research Area:
Epigenetics and Nuclear Signaling

Description

Product Name:HOXA9 Rabbit mAb
Product Code:CAB19257
Size:20uL, 50uL, 100uL
Synonyms:HOXA9, ABD-B, HOX1, HOX1.7, HOX1G, homeobox A9
Applications:WB, IHC
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human HOXA9.
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Rat
Positive Samples:Rat large intestine, Rat liver
Immunogen:Recombinant protein of human HOXA9.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3205
Uniprot:P31269
Cellular Location:Nucleus
Calculated MW:35kDa
Observed MW:30KDa
UniProt Protein Function:HOXA9: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. A chromosomal aberration involving HOXA9 is found in a form of acute myeloid leukemia. Translocation t(7;11)(p15;p15) with NUP98. A chromosomal aberration involving HOXA9 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with MSI2. Belongs to the Abd-B homeobox family.
UniProt Protein Details:

Protein type:DNA-binding; Oncoprotein

Chromosomal Location of Human Ortholog: 7p15.2

Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleus

Molecular Function:protein binding; enzyme binding; sequence-specific DNA binding

Biological Process: embryonic forelimb morphogenesis; negative regulation of myeloid cell differentiation; transcription, DNA-dependent; multicellular organismal development; embryonic skeletal development; male gonad development; uterus development; endothelial cell activation; anterior/posterior pattern formation; regulation of transcription, DNA-dependent; mammary gland development; single fertilization; spermatogenesis; proximal/distal pattern formation

NCBI Summary:In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis. Read-through transcription exists between this gene and the upstream homeobox A10 (HOXA10) gene.[provided by RefSeq, Mar 2011]
UniProt Code:P31269
NCBI GenInfo Identifier:6166219
NCBI Gene ID:3205
NCBI Accession:P31269.4
UniProt Related Accession:P31269
Molecular Weight:
NCBI Full Name:Homeobox protein Hox-A9
NCBI Synonym Full Names:homeobox A9
NCBI Official Symbol:HOXA9  
NCBI Official Synonym Symbols:HOX1; ABD-B; HOX1G; HOX1.7  
NCBI Protein Information:homeobox protein Hox-A9
UniProt Protein Name:Homeobox protein Hox-A9
UniProt Synonym Protein Names:Homeobox protein Hox-1G
UniProt Gene Name:HOXA9  
UniProt Entry Name:HXA9_HUMAN
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