Epigenetics & Nuclear Signaling Antibodies 3
Anti-HOXA9 Antibody (CAB1908)
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- SKU:
- CAB1908
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-HOXA9 Antibody |
| Antibody SKU: | CAB1908 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human HOXA9 (NP_689952.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | SW620 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human HOXA9 (NP_689952.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MATT GALG NYYV DSFL LGAD AADE LSVG RYAP GTLG QPPR QAAT LAEH PDFS PCSF QSKA TVFG ASWN PVHA AGAN AVPA AVYH HHHH HPYV HPQA PVAA AAPD GRYM RSWL EPTP GALS FAGL PSSR PYGI KPEP LSAR RGDC PTLD THTL SLTD YACG SPPV DREK QPSE GAFS ENNA ENES GGDK PP |
| Gene ID: | 3205 |
| Uniprot: | P31269 |
| Cellular Location: | Nucleus |
| Calculated MW: | 30kDa |
| Observed MW: | 38kDa |
| Synonyms: | HOXA9, ABD-B, HOX1, HOX1.7, HOX1G |
| Background: | In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis. Read-through transcription exists between this gene and the upstream homeobox A10 (HOXA10) gene. |
| UniProt Protein Function: | HOXA9: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. A chromosomal aberration involving HOXA9 is found in a form of acute myeloid leukemia. Translocation t(7;11)(p15;p15) with NUP98. A chromosomal aberration involving HOXA9 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with MSI2. Belongs to the Abd-B homeobox family. |
| UniProt Protein Details: | Protein type:DNA-binding; Oncoprotein Chromosomal Location of Human Ortholog: 7p15.2 Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleus Molecular Function:protein binding; enzyme binding; sequence-specific DNA binding Biological Process: embryonic forelimb morphogenesis; negative regulation of myeloid cell differentiation; transcription, DNA-dependent; multicellular organismal development; embryonic skeletal development; male gonad development; uterus development; endothelial cell activation; anterior/posterior pattern formation; regulation of transcription, DNA-dependent; mammary gland development; single fertilization; spermatogenesis; proximal/distal pattern formation |
| NCBI Summary: | In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis. Read-through transcription exists between this gene and the upstream homeobox A10 (HOXA10) gene.[provided by RefSeq, Mar 2011] |
| UniProt Code: | P31269 |
| NCBI GenInfo Identifier: | 6166219 |
| NCBI Gene ID: | 3205 |
| NCBI Accession: | P31269.4 |
| UniProt Related Accession: | P31269 |
| Molecular Weight: | |
| NCBI Full Name: | Homeobox protein Hox-A9 |
| NCBI Synonym Full Names: | homeobox A9 |
| NCBI Official Symbol: | HOXA9 |
| NCBI Official Synonym Symbols: | HOX1; ABD-B; HOX1G; HOX1.7 |
| NCBI Protein Information: | homeobox protein Hox-A9 |
| UniProt Protein Name: | Homeobox protein Hox-A9 |
| UniProt Synonym Protein Names: | Homeobox protein Hox-1G |
| UniProt Gene Name: | HOXA9 |
| UniProt Entry Name: | HXA9_HUMAN |
 | Western blot analysis of extracts of SW620 cells, using HOXA9 antibody (CAB1908) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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