Epigenetics & Nuclear Signaling Antibodies 1

Anti-HOXA7 Antibody (CAB12891)

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SKU:
CAB12891
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-HOXA7 Antibody
Antibody SKU:CAB12891
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human HOXA7 (NP_008827.2).
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human HOXA7 (NP_008827.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSSS YYVN ALFS KYTA GASL FQNA EPTS CSFA PNSQ RSGY GAGA GAFA STVP GLYN VNSP LYQS PFAS GYGL GADA YGNL PCAS YDQN IPGL CSDL AKGA CDKT DEGA LHGA AEAN FRIY
Gene ID:3204
Uniprot:P31268
Cellular Location:Nucleus
Calculated MW:25kDa
Observed MW:25kDa
Synonyms:HOXA7, ANTP, HOX1, HOX1.1, HOX1A
Background:In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila.
UniProt Protein Function:HOXA7: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Antp homeobox family.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 7p15.2

Cellular Component: nucleus

Molecular Function:sequence-specific DNA binding; transcription factor binding

Biological Process: angiogenesis; anterior/posterior pattern formation; embryonic skeletal morphogenesis; negative regulation of cell-matrix adhesion; negative regulation of keratinocyte differentiation; negative regulation of leukocyte migration; negative regulation of monocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; stem cell differentiation; transcription from RNA polymerase II promoter

NCBI Summary:In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila. [provided by RefSeq, Jul 2008]
UniProt Code:P31268
NCBI GenInfo Identifier:311033439
NCBI Gene ID:3204
NCBI Accession:P31268.3
UniProt Secondary Accession:P31268,O43368, O43486, O95655, Q9NSC8, Q9UDM1, A4D191
UniProt Related Accession:P31268
Molecular Weight:25,355 Da
NCBI Full Name:Homeobox protein Hox-A7
NCBI Synonym Full Names:homeobox A7
NCBI Official Symbol:HOXA7  
NCBI Official Synonym Symbols:ANTP; HOX1; HOX1A; HOX1.1  
NCBI Protein Information:homeobox protein Hox-A7
UniProt Protein Name:Homeobox protein Hox-A7
UniProt Synonym Protein Names:Homeobox protein Hox 1.1; Homeobox protein Hox-1A
Protein Family:Homeobox protein
UniProt Gene Name:HOXA7  
UniProt Entry Name:HXA7_HUMAN
Anti-HOXA7 Antibody (CAB12891)Western blot analysis of extracts of various cell lines, using HOXA7 antibody (CAB12891) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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