Name: Anti-HOXA13 Antibody (CAB13999)
Brand: Epigenetics & Nuclear Signaling Antibodies 3
SKU: CAB13999
Availability: OutOfStock

Antibody Name:	Anti-HOXA13 Antibody
Antibody SKU:	CAB13999
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 140-320 of human HOXA13 (NP_000513.2).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human
Positive Samples:	22Rv1, HT-29

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 140-320 of human HOXA13 (NP_000513.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	GPAG PAGA EAAK QCSP CSAA AQSS SGPA ALPY GYFG SGYY PCAR MGPH PNAI KSCA QPAS AAAA AAFA DKYM DTAG PAAE EFSS RAKE FAFY HQGY AAGP YHHH QPMP GYLD MPVV PGLG GPGE SRHE PLGL PMES YQPW ALPN GWNG QMYC PKEQ AQPP HLWK STLP DVVS HPSD ASSY R
Gene ID:	3209
Uniprot:	P31271
Cellular Location:	Nucleus
Calculated MW:	39kDa
Observed MW:	40kDa

Synonyms:

HOXA13, HOX1, HOX1J

Background:

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Expansion of a polyalanine tract in the encoded protein can cause hand-foot-uterus syndrome, also known as hand-foot-genital syndrome.

UniProt Protein Function:	HOXA13: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Defects in HOXA13 are the cause of hand-foot-genital syndrome (HFGS); also known as hand-foot-uterus syndrome. The clinical features include small feet with unusually short great toes and abnormal thumbs. Females with the disorder have duplication of the genital tract. Defects in HOXA13 are the cause of Guttmacher syndrome (GUTTS). Guttmacher syndrome is a dominantly inherited combination of distal limb and genital tract abnormalities. It has several features in common with hand-foot- genital syndrome, including hypoplastic first digits and hypospadias. Typical features not seen in hand-foot-genital syndrome include postaxial polydactyly of the hands and uniphalangeal second toes with absent nails. Belongs to the Abd-B homeobox family.
UniProt Protein Details:	Protein type:DNA-binding Chromosomal Location of Human Ortholog: 7p15.2 Cellular Component: intermediate filament cytoskeleton; nucleus Molecular Function:DNA binding Biological Process: skeletal development Disease: Hand-foot-genital Syndrome; Preaxial Deficiency, Postaxial Polydactyly, And Hypospadias
NCBI Summary:	In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Expansion of a polyalanine tract in the encoded protein can cause hand-foot-uterus syndrome, also known as hand-foot-genital syndrome. [provided by RefSeq, Jul 2008]
UniProt Code:	P31271
NCBI GenInfo Identifier:	116242513
NCBI Gene ID:	3209
NCBI Accession:	P31271.3
UniProt Secondary Accession:	P31271,O43371, A4D188,
UniProt Related Accession:	P31271
Molecular Weight:	39,727 Da
NCBI Full Name:	Homeobox protein Hox-A13
NCBI Synonym Full Names:	homeobox A13
NCBI Official Symbol:	HOXA13
NCBI Official Synonym Symbols:	HOX1; HOX1J
NCBI Protein Information:	homeobox protein Hox-A13
UniProt Protein Name:	Homeobox protein Hox-A13
UniProt Synonym Protein Names:	Homeobox protein Hox-1J
Protein Family:	Homeobox protein
UniProt Gene Name:	HOXA13
UniProt Entry Name:	HXA13_HUMAN

Western blot analysis of extracts of various cell lines, using HOXA13 antibody (CAB13999) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.

Antibodies

Anti-HOXA13 Antibody (CAB9822)

Anti-HOXA13 Antibody (CAB9564)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)