Cell Biology Antibodies 1
Anti-HNRPLL Antibody (CAB10360)
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- SKU:
- CAB10360
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-HNRPLL Antibody |
| Antibody SKU: | CAB10360 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 250-350 of human HNRPLL (NP_612403.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, DU145, HepG2, 293T, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 250-350 of human HNRPLL (NP_612403.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | IRND NDSW DYTK PYLG RRDR GKGR QRQA ILGE HPSS FRHD GYGS HGPL LPLP SRYR MGSR DTPE LVAY PLPQ ASSS YMHG GNPS GSVV MVSG LHQL KMNC S |
| Gene ID: | 92906 |
| Uniprot: | Q8WVV9 |
| Cellular Location: | |
| Calculated MW: | 30kDa/31kDa/56kDa/59kDa/60kDa |
| Observed MW: | 60kDa |
| Synonyms: | HNRNPLL, HNRPLL, SRRF |
| Background: |
| UniProt Protein Function: | HNRPLL: RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC. Interacts with HNRNPL. Up-regulated in stimulated T-cells. Widely expressed. Detected in bone marrow stroma cells, skeletal muscle, heart, placenta, pancreas, kidney and lung. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:RNA-binding Chromosomal Location of Human Ortholog: 2p22.1 Cellular Component: membrane Molecular Function:mRNA binding; protein binding; RNA binding Biological Process: positive regulation of RNA splicing |
| NCBI Summary: | HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).[supplied by OMIM, Aug 2008] |
| UniProt Code: | Q8WVV9 |
| NCBI GenInfo Identifier: | 62286941 |
| NCBI Gene ID: | 92906 |
| NCBI Accession: | Q8WVV9.1 |
| UniProt Secondary Accession: | Q8WVV9,Q53T80, Q5JB51, Q5JB52, Q659B9, Q8IVH5, Q8IVH6 Q96HR5, |
| UniProt Related Accession: | Q8WVV9 |
| Molecular Weight: | 60kDa |
| NCBI Full Name: | Heterogeneous nuclear ribonucleoprotein L-like |
| NCBI Synonym Full Names: | heterogeneous nuclear ribonucleoprotein L like |
| NCBI Official Symbol: | HNRNPLL |
| NCBI Official Synonym Symbols: | SRRF; HNRPLL |
| NCBI Protein Information: | heterogeneous nuclear ribonucleoprotein L-like |
| UniProt Protein Name: | Heterogeneous nuclear ribonucleoprotein L-like |
| UniProt Synonym Protein Names: | Stromal RNA-regulating factor |
| Protein Family: | Heterogeneous nuclear ribonucleoprotein |
| UniProt Gene Name: | HNRNPLL |
 | Western blot analysis of extracts of various cell lines, using HNRNPLL antibody (CAB10360) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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