Name: Anti-HNRPH3 Antibody (CAB8549)
Brand: Epigenetics & Nuclear Signaling Antibodies 4
SKU: CAB8549
Availability: OutOfStock

Antibody Name:	Anti-HNRPH3 Antibody
Antibody SKU:	CAB8549
Antibody Size:	20uL, 50uL, 100uL
Application:	IF
Reactivity:	Human
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-331 of human HNRPH3 (NP_067676.2).

Application:	IF
Recommended Dilution:	IF 1:50 - 1:200
Reactivity:	Human
Positive Samples:

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-331 of human HNRPH3 (NP_067676.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MDWV MKHN GPND ASDG TVRL RGLP FGCS KEEI VQFF QGLE IVPN GITL TMDY QGRS TGEA FVQF ASKE IAEN ALGK HKER IGHR YIEI FRSS RSEI KGFY DPPR RLLG QRPG PYDR PIGG RGGY YGAG RGSY GGFD DYGG YNNY GYGN DGFD DRMR DGRG MGGH GYGG AGDA SSGF HGGH FVHM RGLP FRAT ENDI ANFF SPLN PIRV HIDI GADG RATG EADV EFVT HEDA VAAM SKDK NNMQ HRYI ELFL NSTP GGGS GMGG SGMG GYGR DGMD NQGG YGSV GRMG MGNN YSGG YGTP DGLG GYGR GGGG SGGY YGQG GMSG GGWR GMY
Gene ID:	3189
Uniprot:	P31942
Cellular Location:	Nucleus
Calculated MW:	15kDa/16kDa/22kDa/31kDa/35kDa/36kDa
Observed MW:

Synonyms:

HNRNPH3, 2H9, HNRPH3

Background:

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is localized in nuclear bodies of the nucleus. This protein is involved in the splicing process and it also participates in early heat shock-induced splicing arrest by transiently leaving the hnRNP complexes. Several alternatively spliced transcript variants have been noted for this gene, however, not all are fully characterized.

UniProt Protein Function:	hnRNP 2H9: Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to their great structural variations the different isoforms may possess different functions in the splicing reaction. 6 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:RNA splicing; RNA-binding Chromosomal Location of Human Ortholog: 10q22 Cellular Component: nucleoplasm; spliceosome; nucleus Molecular Function:protein binding; RNA binding; nucleotide binding Biological Process: nuclear mRNA splicing, via spliceosome; RNA processing; epithelial cell differentiation; RNA splicing
NCBI Summary:	This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is localized in nuclear bodies of the nucleus. This protein is involved in the splicing process and it also participates in early heat shock-induced splicing arrest by transiently leaving the hnRNP complexes. Several alternatively spliced transcript variants have been noted for this gene, however, not all are fully characterized. [provided by RefSeq, Jul 2008]
UniProt Code:	P31942
NCBI GenInfo Identifier:	23503095
NCBI Gene ID:	3189
NCBI Accession:	P31942.2
UniProt Secondary Accession:	P31942,Q9BSX1, Q9NP53, Q9NP96, Q9NPA7, Q9NPI4, Q9UFU4 Q9Y4J5, A8K682, B3KRE1,
UniProt Related Accession:	P31942
Molecular Weight:	15,413 Da
NCBI Full Name:	Heterogeneous nuclear ribonucleoprotein H3
NCBI Synonym Full Names:	heterogeneous nuclear ribonucleoprotein H3 (2H9)
NCBI Official Symbol:	HNRNPH3
NCBI Official Synonym Symbols:	2H9; HNRPH3
NCBI Protein Information:	heterogeneous nuclear ribonucleoprotein H3; heterogeneous nuclear ribonucleoprotein 2H9; hnRNP 2H9; hnRNP H3
UniProt Protein Name:	Heterogeneous nuclear ribonucleoprotein H3
UniProt Synonym Protein Names:	Heterogeneous nuclear ribonucleoprotein 2H9; hnRNP 2H9
Protein Family:	Heterogeneous nuclear ribonucleoprotein
UniProt Gene Name:	HNRNPH3
UniProt Entry Name:	HNRH3_HUMAN