Cell Biology Antibodies 9
Anti-HNRNPU Antibody (CAB3917)
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- SKU:
- CAB3917
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-HNRNPU Antibody |
| Antibody SKU: | CAB3917 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF IP |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 608-825 of human HNRNPU (NP_114032.2). |
| Application: | WB IHC IF IP |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 IP 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A431, Jurkat, OVCAR3 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 608-825 of human HNRNPU (NP_114032.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | PKDE DYKQ RTQK KAEV EGKD LPEH AVLK MKGN FTLP EVAE CFDE ITYV ELQK EEAQ KLLE QYKE ESKK ALPP EKKQ NTGS KKSN KNKS GKNQ FNRG GGHR GRGG FNMR GGNF RGGA PGNR GGYN RRGN MPQR GGGG GGSG GIGY PYPR APVF PGRG SYSN RGNY NRGG MPNR GNYN QNFR GRGN NRGY KNQS QGYN QWQQ GQFW GQKP WSQH YHQG YY |
| Gene ID: | 3192 |
| Uniprot: | Q00839 |
| Cellular Location: | Cell surface, Cytoplasm, Nucleus |
| Calculated MW: | 88kDa/90kDa |
| Observed MW: | 120kDa |
| Synonyms: | HNRNPU, EIEE54, HNRNPU-AS1, HNRPU, SAF-A, SAFA, U21.1, hnRNP U, hnRNPU, pp120 |
| Background: | This gene encodes a member of a family of proteins that bind nucleic acids and function in the formation of ribonucleoprotein complexes in the nucleus with heterogeneous nuclear RNA (hnRNA). The encoded protein has affinity for both RNA and DNA, and binds scaffold-attached region (SAR) DNA. Mutations in this gene have been associated with epileptic encephalopathy, early infantile, 54. A pseudogene of this gene has been identified on chromosome 14. |
| UniProt Protein Function: | hnRNP U: Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Binds to double- and single- stranded DNA and RNA. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Spliceosome; Nuclear receptor co-regulator; RNA splicing; DNA-binding; RNA-binding Chromosomal Location of Human Ortholog: 1q44 Cellular Component: nucleoplasm; cell surface; membrane; ribonucleoprotein complex; nucleus Molecular Function:protein binding; DNA binding; RNA binding; ATP binding Biological Process: RNA processing; nuclear mRNA splicing, via spliceosome; osteoblast differentiation; RNA splicing; gene expression; circadian regulation of gene expression |
| NCBI Summary: | This gene encodes a member of a family of proteins that bind nucleic acids and function in the formation of ribonucleoprotein complexes in the nucleus with heterogeneous nuclear RNA (hnRNA). The encoded protein has affinity for both RNA and DNA, and binds scaffold-attached region (SAR) DNA. Mutations in this gene have been associated with epileptic encephalopathy, early infantile, 54. A pseudogene of this gene has been identified on chromosome 14. [provided by RefSeq, Jun 2017] |
| UniProt Code: | Q00839 |
| NCBI GenInfo Identifier: | 254763463 |
| NCBI Gene ID: | 3192 |
| NCBI Accession: | Q00839.6 |
| UniProt Related Accession: | Q00839 |
| Molecular Weight: | |
| NCBI Full Name: | Heterogeneous nuclear ribonucleoprotein U |
| NCBI Synonym Full Names: | heterogeneous nuclear ribonucleoprotein U |
| NCBI Official Symbol: | HNRNPU |
| NCBI Official Synonym Symbols: | SAFA; HNRPU; SAF-A; U21.1; pp120; EIEE54; GRIP120; hnRNP U; HNRNPU-AS1 |
| NCBI Protein Information: | heterogeneous nuclear ribonucleoprotein U |
| UniProt Protein Name: | Heterogeneous nuclear ribonucleoprotein U |
| UniProt Synonym Protein Names: | Scaffold attachment factor A; SAF-A; p120; pp120 |
| Protein Family: | Heterogeneous nuclear ribonucleoprotein |
| UniProt Gene Name: | HNRNPU |
| UniProt Entry Name: | HNRPU_HUMAN |
 | Western blot analysis of extracts of various cell lines, using HNRNPU antibody (CAB3917) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded Mouse brain using HNRNPU Rabbit pAb (CAB3917) at dilution of 1:50 (40x lens). |
 | Immunohistochemistry of paraffin-embedded Rat testis using HNRNPU Rabbit pAb (CAB3917) at dilution of 1:50 (40x lens). |
 | Immunohistochemistry of paraffin-embedded Human esophageal cancer using HNRNPU Rabbit pAb (CAB3917) at dilution of 1:50 (40x lens). |
 | Immunofluorescence analysis of C6 cells using HNRNPU antibody (CAB3917) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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