Cell Biology Antibodies 15
Anti-HNRNPC Antibody (CAB19137)
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- SKU:
- CAB19137
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-HNRNPC Antibody |
| Antibody SKU: | CAB19137 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF IP |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human HNRNPC |
| Application: | WB IHC IF IP |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 IP 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, U-251MG, K-562, Rat testis |
| Immunogen: | Recombinant protein of human HNRNPC |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3183 |
| Uniprot: | P07910 |
| Cellular Location: | Nucleus |
| Calculated MW: | 25kDa/27kDa/32kDa/33kDa |
| Observed MW: | 40kDa/42kDa |
 | Western blot - HNRNPC Rabbit pAb (CAB19137) |
| Synonyms: | HNRNPC, C1, C2, HNRNP, HNRPC, SNRPC |
| Background: | This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. |
| UniProt Protein Function: | hnRNP C1/C2: a heterogeneous nuclear ribonucleoprotein. May play a role in ribonucleosome assembly by neutralizing basic proteins such as A and B core hnRNP. Contains 1 RNA recognition motif (RRM) domain. Two alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Spliceosome; RNA-binding; RNA splicing Chromosomal Location of Human Ortholog: 14q11.2 Cellular Component: cytosol; membrane; nuclear chromatin; nucleoplasm; nucleus; protein complex; spliceosome; telomerase holoenzyme complex Molecular Function:identical protein binding; mRNA 3'-UTR binding; nucleosomal DNA binding; nucleotide binding; poly(U) binding; protein binding; RNA binding Biological Process: ATP-dependent chromatin remodeling; cellular protein metabolic process; gene expression; negative regulation of telomere maintenance via telomerase; nuclear mRNA splicing, via spliceosome; osteoblast differentiation; post-translational protein modification; protein sumoylation; RNA splicing |
| NCBI Summary: | This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P07910 |
| NCBI GenInfo Identifier: | 108935845 |
| NCBI Gene ID: | 3183 |
| NCBI Accession: | P07910.4 |
| UniProt Secondary Accession: | P07910,P22628, Q53EX2, Q59FD3, Q5FWE8, Q86SF8, Q86U45 Q96HK7, Q96HM4, Q96IY5, D3DS19, D3DS22, |
| UniProt Related Accession: | P07910 |
| Molecular Weight: | 27,822 Da |
| NCBI Full Name: | Heterogeneous nuclear ribonucleoproteins C1/C2 |
| NCBI Synonym Full Names: | heterogeneous nuclear ribonucleoprotein C (C1/C2) |
| NCBI Official Symbol: | HNRNPC |
| NCBI Official Synonym Symbols: | C1; C2; HNRNP; HNRPC; SNRPC |
| NCBI Protein Information: | heterogeneous nuclear ribonucleoproteins C1/C2 |
| UniProt Protein Name: | Heterogeneous nuclear ribonucleoproteins C1/C2 |
| Protein Family: | Heterogeneous nuclear ribonucleoprotein |
| UniProt Gene Name: | HNRNPC |
| UniProt Entry Name: | HNRPC_HUMAN |
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