Immunology Antibodies 3

Anti-hnRNP Q Antibody (CAB9609)

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SKU:
CAB9609
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-hnRNP Q Antibody
Antibody SKU:CAB9609
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human hnRNP Q
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, Mouse brain, Mouse heart, Rat lung, Rat spleen, Rat thymus
Immunogen:A synthesized peptide derived from human hnRNP Q
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10492
Uniprot:O60506
Cellular Location:
Calculated MW:65-82kDa
Observed MW:70-85KDa
Synonyms:GRY-RBP, GRYRBP, HNRNPQ, HNRPQ1, NSAP1, PP68, hnRNP-Q
Background:This gene encodes a member of the cellular heterogeneous nuclear ribonucleoprotein (hnRNP) family. hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA) and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. The encoded protein plays a role in multiple aspects of mRNA maturation and is associated with several multiprotein complexes including the apoB RNA editing-complex and survival of motor neurons (SMN) complex. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 20. [provided by RefSeq, Dec 2011]
UniProt Protein Function:NSAP1: a heterogeneous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. A component of the spliceosome. Five alternatively spliced isoforms have been described. Isoform 1, 2 and 3 are associated with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to ACF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins.
UniProt Protein Details:

Protein type:RNA splicing; Motility/polarity/chemotaxis; Spliceosome; RNA-binding

Chromosomal Location of Human Ortholog: 6q14-q15

Cellular Component: membrane; nucleus; ribonucleoprotein complex

Molecular Function:protein binding; RNA binding

Biological Process: negative regulation of translation; nuclear mRNA splicing, via spliceosome; osteoblast differentiation; RNA processing; RNA splicing

NCBI Summary:This gene encodes a member of the cellular heterogeneous nuclear ribonucleoprotein (hnRNP) family. hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA) and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. The encoded protein plays a role in multiple aspects of mRNA maturation and is associated with several multiprotein complexes including the apoB RNA editing-complex and survival of motor neurons (SMN) complex. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 20. [provided by RefSeq, Dec 2011]
UniProt Code:O60506
NCBI GenInfo Identifier:92090361
NCBI Gene ID:10492
NCBI Accession:O60506.2
UniProt Secondary Accession:O60506,Q53H05, Q5TCG2, Q5TCG3, Q8IW78, Q8N599, Q96LC1 Q96LC2, Q9Y583, E1P501, E1P502,
UniProt Related Accession:O60506
Molecular Weight:46,328 Da
NCBI Full Name:Heterogeneous nuclear ribonucleoprotein Q
NCBI Synonym Full Names:synaptotagmin binding cytoplasmic RNA interacting protein
NCBI Official Symbol:SYNCRIP  
NCBI Official Synonym Symbols:PP68; NSAP1; GRYRBP; HNRNPQ; HNRPQ1; GRY-RBP; hnRNP-Q  
NCBI Protein Information:heterogeneous nuclear ribonucleoprotein Q
UniProt Protein Name:Heterogeneous nuclear ribonucleoprotein Q
UniProt Synonym Protein Names:Glycine- and tyrosine-rich RNA-binding protein; GRY-RBP; NS1-associated protein 1; Synaptotagmin-binding, cytoplasmic RNA-interacting protein
Protein Family:Heterogeneous nuclear ribonucleoprotein
UniProt Gene Name:SYNCRIP  
UniProt Entry Name:HNRPQ_HUMAN
Anti-hnRNP Q Antibody (CAB9609)Western blot - hnRNP Q Rabbit mAb (CAB9609)
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