Epigenetics & Nuclear Signaling Antibodies 3
Anti-HNF1B Antibody (CAB3093)
- SKU:
- CAB3093
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-HNF1B Antibody |
| Antibody SKU: | CAB3093 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human HNF1B (NP_000449.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Rat |
| Positive Samples: |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human HNF1B (NP_000449.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TEEA AEQR AEVD RMLS EDPW RAAK MIKG YMQQ HNIP QREV VDVT GLNQ SHLS QHLN KGTP MKTQ KRAA LYTW YVRK QREI LRQF NQTV QSSG NMTD KSSQ D |
| Gene ID: | 6928 |
| Uniprot: | P35680 |
| Cellular Location: | Nucleus |
| Calculated MW: | 44kDa/46kDa/58kDa/61kDa |
| Observed MW: | Refer to figures |
| Synonyms: | HNF1B, FJHN, HNF-1-beta, HNF-1B, HNF1beta, HNF2, HPC11, LF-B3, LFB3, MODY5, TCF-2, TCF2, VHNF1 |
| Background: | This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | TCF2: Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in HNF1B are the cause of renal cysts and diabetes syndrome (RCAD); also called maturity-onset diabetes of the young type 5 (MODY5) or familial hypoplastic glomerulocystic kidney disease (GCKD). RCAD is an autosomal dominant disorder comprising non-diabetic renal disease resulting from abnormal renal development, and diabetes, which in some cases occurs earlier than age 25 years and is thus consistent with a diagnosis of maturity-onset diabetes of the young (MODY5). The renal disease is highly variable and includes renal cysts, glomerular tufts, aberrant nephrogenesis, primitive tubules, irregular collecting systems, oligomeganephronia, enlarged renal pelves, abnormal calyces, small kidney, single kidney, horseshoe kidney, and hyperuricemic nephropathy. Defects in HNF1B may be rare genetic risk factor contributing to the development of non-insulin-dependent diabetes mellitus (NIDDM). NIDDM is characterized by an autosomal dominant mode of inheritance, onset during adulthood and insulin resistance. Defects in HNF1B may be a cause of susceptibility to prostate cancer hereditary type 11 (HPC11). It is a condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Belongs to the HNF1 homeobox family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 17q12 Cellular Component: nucleoplasm; nucleus; transcription factor complex Molecular Function:DNA binding; protein binding; protein complex binding; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; transcription factor activity Biological Process: anterior/posterior pattern formation; branching morphogenesis of a tube; circadian regulation of gene expression; embryonic digestive tract morphogenesis; endocrine pancreas development; endodermal cell fate specification; epithelial cell proliferation; genitalia development; hindbrain development; inner cell mass cell differentiation; insulin secretion; kidney development; negative regulation of transcription from RNA polymerase II promoter; Notch signaling pathway; positive regulation of transcription, DNA-dependent; pronephros development; protein-DNA complex assembly; regulation of endodermal cell fate specification; regulation of Wnt receptor signaling pathway; response to drug; response to glucose stimulus; response to organic cyclic substance; transcription, DNA-dependent Disease: Diabetes Mellitus, Noninsulin-dependent; Renal Cell Carcinoma, Nonpapillary; Renal Cysts And Diabetes Syndrome |
| NCBI Summary: | This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] |
| UniProt Code: | P35680 |
| NCBI GenInfo Identifier: | 547664 |
| NCBI Gene ID: | 6928 |
| NCBI Accession: | P35680.1 |
| UniProt Secondary Accession: | P35680,B4DKM3, E0YMJ9, |
| UniProt Related Accession: | P35680 |
| Molecular Weight: | 46,907 Da |
| NCBI Full Name: | Hepatocyte nuclear factor 1-beta |
| NCBI Synonym Full Names: | HNF1 homeobox B |
| NCBI Official Symbol: | HNF1B |
| NCBI Official Synonym Symbols: | FJHN; HNF2; LFB3; TCF2; HPC11; LF-B3; MODY5; TCF-2; VHNF1; HNF-1B; HNF1beta; HNF-1-beta |
| NCBI Protein Information: | hepatocyte nuclear factor 1-beta |
| UniProt Protein Name: | Hepatocyte nuclear factor 1-beta |
| UniProt Synonym Protein Names: | Homeoprotein LFB3; Transcription factor 2; TCF-2; Variant hepatic nuclear factor 1; vHNF1 |
| Protein Family: | Hepatocyte nuclear factor |
| UniProt Gene Name: | HNF1B |
| UniProt Entry Name: | HNF1B_HUMAN |
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