Immunology Antibodies 2
Anti-HLA-G Antibody (CAB7557)
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- SKU:
- CAB7557
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-HLA-G Antibody |
| Antibody SKU: | CAB7557 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-230 of human HLA-G (NP_002118.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | THP-1, Human placenta |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-230 of human HLA-G (NP_002118.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TETW AGSH SMRY FSAA VSRP GRGE PRFI AMGY VDDT QFVR FDSD SACP RMEP RAPW VEQE GPEY WEEE TRNT KAHA QTDR MNLQ TLRG YYNQ SEAS SHTL QWMI GCDL GSDG RLLR GYEQ YAYD GKDY LALN EDLR SWTA ADTA AQIS KRKC EAAN VAEQ RRAY LEGT CVEW LHRY LENG KEML QRAD PPKT HVTH HPVF DYEA TLRC WAL |
| Gene ID: | 3135 |
| Uniprot: | P17693 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 38kDa |
| Observed MW: | 43kDa |
| Synonyms: | MHC-G, HLA-G |
| Background: | HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. |
| NCBI Summary: | HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P17693 |
| NCBI GenInfo Identifier: | 122132 |
| NCBI Gene ID: | 3135 |
| NCBI Accession: | P17693.1 |
| UniProt Related Accession: | P17693 |
| Molecular Weight: | Predicted Molecular Mass: 36.4kDaAccurate Molecular Mass: 38kDa as determined by SDS-PAGE reducing conditions. |
| NCBI Full Name: | HLA class I histocompatibility antigen, alpha chain G |
| NCBI Synonym Full Names: | major histocompatibility complex, class I, G |
| NCBI Official Symbol: | HLA-G |
| NCBI Official Synonym Symbols: | MHC-G |
| NCBI Protein Information: | HLA class I histocompatibility antigen, alpha chain G |
| UniProt Protein Name: | HLA class I histocompatibility antigen, alpha chain G |
| UniProt Synonym Protein Names: | HLA G antigen; MHC class I antigen G |
| UniProt Gene Name: | HLA-G |
| UniProt Entry Name: | HLAG_HUMAN |
 | Western blot analysis of extracts of various cell lines, using HLA-G antibody (CAB7557) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
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