| Background: | HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. |
| UniProt Protein Function: | HLA-E: Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules. Belongs to the MHC class I family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: Golgi membrane; phagocytic vesicle membrane; cell surface; early endosome membrane; plasma membrane; MHC class I protein complex Molecular Function:peptide antigen binding; MHC class I protein binding; beta-2-microglobulin binding; receptor binding Biological Process: regulation of immune response; antigen processing and presentation of peptide antigen via MHC class I; positive regulation of T cell mediated cytotoxicity; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; cytokine and chemokine mediated signaling pathway; positive regulation of natural killer cell mediated immunity; regulation of natural killer cell mediated immunity; antigen processing and presentation of exogenous peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; innate immune response; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; protection from natural killer cell mediated cytotoxicity |
| NCBI Summary: | HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P13747 |
| NCBI GenInfo Identifier: | 62912479 |
| NCBI Gene ID: | 3133 |
| NCBI Accession: | NP_005507.3 |
| UniProt Secondary Accession: | P13747,Q30169, Q9BT83, Q9GIY7, Q9GIY8, |
| UniProt Related Accession: | P13747 |
| Molecular Weight: | 40,157 Da |
| NCBI Full Name: | HLA class I histocompatibility antigen, alpha chain E |
| NCBI Synonym Full Names: | major histocompatibility complex, class I, E |
| NCBI Official Symbol: | HLA-E |
| NCBI Official Synonym Symbols: | MHC; QA1; EA1.2; EA2.1; HLA-6.2 |
| NCBI Protein Information: | HLA class I histocompatibility antigen, alpha chain E; HLA class I histocompatibility antigen, E alpha chain; MHC HLA-E alpha-1; MHC HLA-E alpha-2.1; MHC class I antigen E; lymphocyte antigen |
| UniProt Protein Name: | HLA class I histocompatibility antigen, alpha chain E |
| UniProt Synonym Protein Names: | MHC class I antigen E |
| UniProt Gene Name: | HLA-E |
| UniProt Entry Name: | HLAE_HUMAN |
