Immunology Antibodies 3
Anti-HLA-DQA1 Antibody (CAB11252)
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- SKU:
- CAB11252
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-HLA-DQA1 Antibody |
| Antibody SKU: | CAB11252 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human HLA-DQA1 |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Raji, Mouse lung, Mouse spleen, Rat lung, Rat spleen |
| Immunogen: | A synthesized peptide derived from human HLA-DQA1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3117 |
| Uniprot: | P01909 |
| Cellular Location: | |
| Calculated MW: | 28kDa |
| Observed MW: | 28KDa |
 | Western blot - HLA-DQA1 Rabbit mAb (CAB11252) |
| Synonyms: | CELIAC1, DQ-A1, HLA-DQA |
| Background: | HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | HLA-DQA1 iso4: |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cell surface Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: Golgi membrane; membrane; lysosomal membrane; integral to plasma membrane; plasma membrane; trans-Golgi network membrane; endosome membrane; MHC class II protein complex; external side of plasma membrane Molecular Function:MHC class II receptor activity; peptide antigen binding Biological Process: positive regulation of T cell differentiation; cytokine and chemokine mediated signaling pathway; T cell costimulation; antigen processing and presentation of exogenous peptide antigen via MHC class II; immune response; T cell receptor signaling pathway |
| NCBI Summary: | HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P01909 |
| NCBI GenInfo Identifier: | 122188 |
| NCBI Gene ID: | 3117 |
| NCBI Accession: | P01909.1 |
| UniProt Related Accession: | P01909 |
| Molecular Weight: | |
| NCBI Full Name: | HLA class II histocompatibility antigen, DQ alpha 1 chain |
| NCBI Synonym Full Names: | major histocompatibility complex, class II, DQ alpha 1 |
| NCBI Official Symbol: | HLA-DQA1 |
| NCBI Official Synonym Symbols: | DQA1; DQ-A1; CELIAC1; HLA-DQA |
| NCBI Protein Information: | HLA class II histocompatibility antigen, DQ alpha 1 chain |
| UniProt Protein Name: | HLA class II histocompatibility antigen, DQ alpha 1 chain |
| UniProt Synonym Protein Names: | DC-1 alpha chain; DC-alpha; HLA-DCA; MHC class II DQA1 |
| Protein Family: | HLA class II histocompatibility antigen |
| UniProt Gene Name: | HLA-DQA1 |
| UniProt Entry Name: | DQA1_HUMAN |
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