Anti-HLA-DMB Antibody (CAB0948)
- SKU:
- CAB0948
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- HLA-DMB
- Synonyms:
- D6S221E
- Synonyms:
- RING7
- Synonyms:
- major histocompatibility complex
- Synonyms:
- class II
- Synonyms:
- DM beta
- Research Area:
- Immunology
Description
| Product Name: | HLA-DMB Rabbit mAb |
| Product Code: | CAB0948 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | HLA-DMB, D6S221E, RING7, major histocompatibility complex, class II, DM beta |
| Applications: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human HLA-DMB. |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HT-29, Raji |
| Immunogen: | A synthesized peptide derived from human HLA-DMB. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3109 |
| Uniprot: | P28068 |
| Cellular Location: | Late endosome membrane, Lysosome membrane, Single-pass type I membrane protein |
| Calculated MW: | 29kDa |
| Observed MW: | 29KDa |
| UniProt Protein Function: | HLA-DMB: Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Belongs to the MHC class II family. |
| UniProt Protein Details: | Protein type:Vesicle; Membrane protein, integral Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: lysosomal membrane; late endosome membrane; integral to membrane; MHC class II protein complex Biological Process: peptide antigen assembly with MHC class II protein complex; antigen processing and presentation of exogenous peptide antigen via MHC class II; positive regulation of T cell proliferation; immune response; MHC class II protein complex assembly |
| NCBI Summary: | HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P28068 |
| NCBI GenInfo Identifier: | 133160 |
| NCBI Gene ID: | 3109 |
| NCBI Accession: | P28068.1 |
| UniProt Related Accession: | P28068 |
| Molecular Weight: | |
| NCBI Full Name: | HLA class II histocompatibility antigen, DM beta chain |
| NCBI Synonym Full Names: | major histocompatibility complex, class II, DM beta |
| NCBI Official Symbol: | HLA-DMB |
| NCBI Official Synonym Symbols: | RING7; D6S221E |
| NCBI Protein Information: | HLA class II histocompatibility antigen, DM beta chain |
| UniProt Protein Name: | HLA class II histocompatibility antigen, DM beta chain |
| UniProt Synonym Protein Names: | MHC class II antigen DMB; Really interesting new gene 7 protein |
| Protein Family: | HLA class II histocompatibility antigen |
| UniProt Gene Name: | HLA-DMB |
| UniProt Entry Name: | DMB_HUMAN |
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