| Background: | HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. |
| UniProt Protein Function: | Involved in the presentation of foreign antigens to the immune system. |
| NCBI Summary: | HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P04439 |
| NCBI GenInfo Identifier: | 13124681 |
| NCBI Gene ID: | 3105 |
| NCBI Accession: | P01891.4 |
| UniProt Secondary Accession: | P04439,O19673, O19695, O19794, O19795, O43907, O77938 O98010, P10315, P79505, Q9MYA5, Q9MYC4, |
| UniProt Related Accession: | P01891,P01892,P04439,P05534,P10314,P10316,P13746,P16188,P16189,P16190 |
| Molecular Weight: | 40,909 Da |
| NCBI Full Name: | HLA class I histocompatibility antigen, A-68 alpha chain |
| NCBI Synonym Full Names: | major histocompatibility complex, class I, A |
| NCBI Official Symbol: | HLA-A |
| NCBI Official Synonym Symbols: | HLAA |
| NCBI Protein Information: | HLA class I histocompatibility antigen, A-1 alpha chain; LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A-1 alpha chain |
| UniProt Protein Name: | HLA class I histocompatibility antigen, A-68 alpha chain |
| UniProt Synonym Protein Names: | Aw-68; HLA class I histocompatibility antigen, A-28 alpha chain; MHC class I antigen A*68 |
| Protein Family: | HLA class I histocompatibility antigen |
| UniProt Gene Name: | HLA-A |
