| UniProt Protein Function: | H2B1K: a core component of the nucleoosome. The nucleosome, a basic organizational unit of chromosomal DNA, is octrameric, consisting of two molecules each of histones H2B, H2A, H3, H4. The octamer wraps approximately 147 bp of DNA. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 6p21.33Cellular Component: nucleoplasm; extracellular space; nucleosome; nucleusMolecular Function: DNA binding; protein heterodimerization activityBiological Process: establishment and/or maintenance of chromatin architecture; defense response to Gram-positive bacterium; innate immune response in mucosa; antibacterial humoral response |
| UniProt Protein Details: | |
| NCBI Summary: | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family. The protein encoded is an antimicrobial protein with antibacterial and antifungal activity. Two transcripts that encode the same protein have been identified for this gene, which is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015] |
| UniProt Code: | O60814 |
| NCBI GenInfo Identifier: | 18105048 |
| NCBI Gene ID: | 85236 |
| NCBI Accession: | NP_542160.1 |
| UniProt Secondary Accession: | O60814,P06899, P23527, P33778, P57053, P58876, P62807 Q16778, Q5QNW6, Q8N257 |
| UniProt Related Accession: | O60814 |
| Molecular Weight: | 14kDa |
| NCBI Full Name: | histone H2B type 1-K |
| NCBI Synonym Full Names: | H2B clustered histone 12 |
| NCBI Official Symbol: | H2BC12 |
| NCBI Official Synonym Symbols: | H2BK; H2B/S; H2BFT; H2BFAiii; HIST1H2BK |
| NCBI Protein Information: | histone H2B type 1-K |
| UniProt Protein Name: | Histone H2B type 1-K |
| UniProt Synonym Protein Names: | HIRA-interacting protein 1 |
| Protein Family: | Histone |
| UniProt Gene Name: | HIST1H2BK |
| UniProt Entry Name: | H2B1K_HUMAN |
