Cell Biology Antibodies 17

Anti-Histone H2A.Z Antibody (CAB4599)

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SKU:
CAB4599
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
H2A.Z-1
Synonyms:
H2A.z
Synonyms:
H2A/z
Synonyms:
H2AZ
Research Area:
Cell Biology

Description

Product Name:Histone H2A.Z Rabbit mAb
Product Code:CAB4599
Size:20uL, 50uL, 100uL
Synonyms:H2A.Z-1, H2A.z, H2A/z, H2AZ
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Histone H2A.Z
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, 293T, U-87MG, Mouse lung, Mouse testis, Mouse brain, Rat lung, Rat testis
Immunogen:A synthesized peptide derived from human Histone H2A.Z
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3015
Uniprot:P0C0S5
Calculated MW:13kDa
Observed MW:15KDa
UniProt Protein Function:H2AZ: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AFZ forms an heterodimer with H2B. H2AFZ interacts with INCENP. Belongs to the histone H2A family.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 4q23

Cellular Component: Barr body; nuclear heterochromatin; nucleus

Molecular Function:chromatin DNA binding; nucleosomal DNA binding; protein binding

Biological Process: chromatin silencing; positive regulation of transcription from RNA polymerase II promoter

NCBI Summary:Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality. [provided by RefSeq, Jul 2008]
UniProt Code:P0C0S5
NCBI GenInfo Identifier:83288408
NCBI Gene ID:3015
NCBI Accession:P0C0S5.2
UniProt Secondary Accession:P0C0S5,P17317, Q6I9U0, B2RD56,
UniProt Related Accession:P0C0S5
Molecular Weight:14kDa
NCBI Full Name:Histone H2A.Z
NCBI Synonym Full Names:H2A histone family member Z
NCBI Official Symbol:H2AFZ  
NCBI Official Synonym Symbols:H2AZ; H2A.z; H2A/z; H2A.Z-1  
NCBI Protein Information:histone H2A.Z
UniProt Protein Name:Histone H2A.Z
UniProt Gene Name:H2AFZ  
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