Name: Anti-HIPK2 Antibody (CAB9552)
Brand: Cell Biology Antibodies 15
SKU: CAB9552
Availability: OutOfStock

Antibody Name:	Anti-HIPK2 Antibody
Antibody SKU:	CAB9552
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IF
Reactivity:	Human
Host Species:	Rabbit
Immunogen:	A synthesized peptide derived from human HIPK2

Application:	WB IF
Recommended Dilution:	WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:	Human
Positive Samples:	RD, Raji

Immunogen:	A synthesized peptide derived from human HIPK2
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	28996
Uniprot:	Q9H2X6
Cellular Location:
Calculated MW:	130/100kDa
Observed MW:	105KDa/131KDa

Synonyms:

PRO0593

Background:

This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

UniProt Protein Function:	HIPK2: homeodomain interacting protein kinase 2 is a CMGC kinase of the DYRK family. Interacts with TRADD. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Inhibits cell growth and promotes apoptosis. Involved in transcriptional activation of TP53 and TP73. In response to TGFB, cooperates with DAXX to activate JNK. Phosphorylates the antiapoptotic factor CTBP1 and promotes its proteasomal degradation. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between TAK1 and NLK to promote the proteasomal degradation of MYB. Highly expressed in neuronal tissues, heart and kidney. Weakly expressed ubiquitously. Possible tumor suppressor. Activates p53 in response to UV light, causing growth arrest and apoptosis. Required for cisplatin-induced apoptosis. Downregulated in breast and thyroid carcinomas. Three alternatively spliced isoforms have been described.
UniProt Protein Details:	Protein type:Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CMGC; CMGC group; DYRK family; HIPK subfamily Chromosomal Location of Human Ortholog: 7q34 Cellular Component: cytoplasm; nuclear body; nucleoplasm; nucleus; PML body Molecular Function:protein binding; protein kinase activity; protein serine/threonine kinase activity; SMAD binding; transcription corepressor activity; virion binding Biological Process: DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; erythrocyte differentiation; eye development; negative regulation of BMP signaling pathway; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; PML body organization and biogenesis; positive regulation of angiogenesis; positive regulation of JNK cascade; positive regulation of protein binding; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor beta receptor signaling pathway; protein amino acid phosphorylation; regulation of cell cycle
NCBI Summary:	This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
UniProt Code:	Q9H2X6
NCBI GenInfo Identifier:	21431782
NCBI Gene ID:	28996
NCBI Accession:	Q9H2X6.2
UniProt Secondary Accession:	Q9H2X6,Q75MR7, Q8WWI4, Q9H2Y1,
UniProt Related Accession:	Q9H2X6
Molecular Weight:	128,158 Da
NCBI Full Name:	Homeodomain-interacting protein kinase 2
NCBI Synonym Full Names:	homeodomain interacting protein kinase 2
NCBI Official Symbol:	HIPK2
NCBI Official Synonym Symbols:	PRO0593
NCBI Protein Information:	homeodomain-interacting protein kinase 2
UniProt Protein Name:	Homeodomain-interacting protein kinase 2
Protein Family:	Homeodomain-interacting protein kinase
UniProt Gene Name:	HIPK2
UniProt Entry Name:	HIPK2_HUMAN