Cell Biology Antibodies 15
Anti-HIPK2 Antibody (CAB9552)
- SKU:
- CAB9552
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
Description
Antibody Name: | Anti-HIPK2 Antibody |
Antibody SKU: | CAB9552 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IF |
Reactivity: | Human |
Host Species: | Rabbit |
Immunogen: | A synthesized peptide derived from human HIPK2 |
Application: | WB IF |
Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
Reactivity: | Human |
Positive Samples: | RD, Raji |
Immunogen: | A synthesized peptide derived from human HIPK2 |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | Email for sequence |
Gene ID: | 28996 |
Uniprot: | Q9H2X6 |
Cellular Location: | |
Calculated MW: | 130/100kDa |
Observed MW: | 105KDa/131KDa |
Synonyms: | PRO0593 |
Background: | This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] |
UniProt Protein Function: | HIPK2: homeodomain interacting protein kinase 2 is a CMGC kinase of the DYRK family. Interacts with TRADD. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Inhibits cell growth and promotes apoptosis. Involved in transcriptional activation of TP53 and TP73. In response to TGFB, cooperates with DAXX to activate JNK. Phosphorylates the antiapoptotic factor CTBP1 and promotes its proteasomal degradation. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between TAK1 and NLK to promote the proteasomal degradation of MYB. Highly expressed in neuronal tissues, heart and kidney. Weakly expressed ubiquitously. Possible tumor suppressor. Activates p53 in response to UV light, causing growth arrest and apoptosis. Required for cisplatin-induced apoptosis. Downregulated in breast and thyroid carcinomas. Three alternatively spliced isoforms have been described. |
UniProt Protein Details: | Protein type:Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CMGC; CMGC group; DYRK family; HIPK subfamily Chromosomal Location of Human Ortholog: 7q34 Cellular Component: cytoplasm; nuclear body; nucleoplasm; nucleus; PML body Molecular Function:protein binding; protein kinase activity; protein serine/threonine kinase activity; SMAD binding; transcription corepressor activity; virion binding Biological Process: DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; erythrocyte differentiation; eye development; negative regulation of BMP signaling pathway; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; PML body organization and biogenesis; positive regulation of angiogenesis; positive regulation of JNK cascade; positive regulation of protein binding; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor beta receptor signaling pathway; protein amino acid phosphorylation; regulation of cell cycle |
NCBI Summary: | This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] |
UniProt Code: | Q9H2X6 |
NCBI GenInfo Identifier: | 21431782 |
NCBI Gene ID: | 28996 |
NCBI Accession: | Q9H2X6.2 |
UniProt Secondary Accession: | Q9H2X6,Q75MR7, Q8WWI4, Q9H2Y1, |
UniProt Related Accession: | Q9H2X6 |
Molecular Weight: | 128,158 Da |
NCBI Full Name: | Homeodomain-interacting protein kinase 2 |
NCBI Synonym Full Names: | homeodomain interacting protein kinase 2 |
NCBI Official Symbol: | HIPK2 |
NCBI Official Synonym Symbols: | PRO0593 |
NCBI Protein Information: | homeodomain-interacting protein kinase 2 |
UniProt Protein Name: | Homeodomain-interacting protein kinase 2 |
Protein Family: | Homeodomain-interacting protein kinase |
UniProt Gene Name: | HIPK2 |
UniProt Entry Name: | HIPK2_HUMAN |