Epigenetics & Nuclear Signaling Antibodies 5
Anti-HIF1Beta/ARNT Antibody (CAB19532)
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- SKU:
- CAB19532
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-HIF1Beta/ARNT Antibody |
| Antibody SKU: | CAB19532 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human HIF-1 beta. |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: | HeLa |
| Immunogen: | A synthesized peptide derived from human HIF-1 beta. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 405 |
| Uniprot: | P27540 |
| Cellular Location: | |
| Calculated MW: | 87kDa |
| Observed MW: | 87KDa |
 | Western blot - HIF1Beta/ARNT Rabbit mAb (CAB19532) |
| Synonyms: | ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 |
| Background: | This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013] |
| UniProt Protein Function: | Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia. |
| NCBI Summary: | This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013] |
| UniProt Code: | P27540 |
| NCBI GenInfo Identifier: | 114163 |
| NCBI Gene ID: | 405 |
| NCBI Accession: | P27540.1 |
| UniProt Secondary Accession: | P27540,Q59ED4, Q5QP39, Q8NDC7, B2R9H1, C4AMA1, F8WAP6 |
| UniProt Related Accession: | P27540 |
| Molecular Weight: | 86,366 Da |
| NCBI Full Name: | Aryl hydrocarbon receptor nuclear translocator |
| NCBI Synonym Full Names: | aryl hydrocarbon receptor nuclear translocator |
| NCBI Official Symbol: | ARNT |
| NCBI Official Synonym Symbols: | HIF1B; TANGO; bHLHe2; HIF1BETA; HIF-1beta; HIF1-beta; HIF-1-beta |
| NCBI Protein Information: | aryl hydrocarbon receptor nuclear translocator |
| UniProt Protein Name: | Aryl hydrocarbon receptor nuclear translocator |
| UniProt Synonym Protein Names: | Class E basic helix-loop-helix protein 2; bHLHe2; Dioxin receptor, nuclear translocator; Hypoxia-inducible factor 1-beta; HIF-1-beta; HIF1-beta |
| Protein Family: | Aryl hydrocarbon receptor nuclear translocator |
| UniProt Gene Name: | ARNT |
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