Cell Biology Antibodies 3
Anti-HHLA2 Antibody (CAB13262)
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- SKU:
- CAB13262
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-HHLA2 Antibody |
| Antibody SKU: | CAB13262 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-200 of human HHLA2 (NP_009003.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-200 of human HHLA2 (NP_009003.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | IYVP MNEQ IVIG RLDE DIIL PSSF ERGS EVVI HWKY QDSY KVHS YYKG SDHL ESQD PRYA NRTS LFYN EIQN GNAS LFFR RVSL LDEG IYTC YVGT AIQV ITNK VVLK VGVF LTPV MKYE KRNT NSFL ICSV LSVY PRPI ITWK MDNT PISE NNME ETGS LDSF SINS PLN |
| Gene ID: | 11148 |
| Uniprot: | Q9UM44 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 39kDa/46kDa |
| Observed MW: | Refer to figures |
| Synonyms: | HHLA2, B7-H5, B7-H7, B7H7, B7y |
| Background: | This gene encodes a protein ligand found on the surface of monocytes. The encoded protein is thought to regulate cell-mediated immunity by binding to a receptor on T lymphocytes and inhibiting the proliferation of these cells. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | HHLA2: Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. Up-regulated in antigen-presenting cells in response to inflammation. Induced in dendritic cells in response to IFNG, poly(I:C) or heat-killed Listeria monocytogenes (at protein level). Interacts with TMIGD2. 2 isoforms of the human protein are produced by alternative splicing |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 3q13.13 Cellular Component: integral to membrane Molecular Function:protein binding Biological Process: positive regulation of cytokine production; T cell costimulation; positive regulation of activated T cell proliferation |
| NCBI Summary: | This gene encodes a protein ligand found on the surface of monocytes. The encoded protein is thought to regulate cell-mediated immunity by binding to a receptor on T lymphocytes and inhibiting the proliferation of these cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] |
| UniProt Code: | Q9UM44 |
| NCBI GenInfo Identifier: | 5901964 |
| NCBI Gene ID: | 11148 |
| NCBI Accession: | NP_009003.1 |
| UniProt Secondary Accession: | Q9UM44,Q9NWQ6, B4DKN2, D3DN60, |
| UniProt Related Accession: | Q9UM44 |
| Molecular Weight: | |
| NCBI Full Name: | HERV-H LTR-associating protein 2 isoform a |
| NCBI Synonym Full Names: | HERV-H LTR-associating 2 |
| NCBI Official Symbol: | HHLA2 |
| NCBI Official Synonym Symbols: | B7H7; B7-H7 |
| NCBI Protein Information: | HERV-H LTR-associating protein 2 |
| UniProt Protein Name: | HERV-H LTR-associating protein 2 |
| UniProt Synonym Protein Names: | Human endogenous retrovirus-H long terminal repeat-associating protein 2 |
| Protein Family: | HERV-H LTR-associating protein |
| UniProt Gene Name: | HHLA2 |
| UniProt Entry Name: | HHLA2_HUMAN |
 | Immunohistochemistry of paraffin-embedded human colon using HHLA2 antibody (CAB13262) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human lung using HHLA2 antibody (CAB13262) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using HHLA2 antibody (CAB13262) at dilution of 1:100 (40x lens). |
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