Cell Biology Antibodies 8
Anti-HHIP Antibody (CAB3260)
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- SKU:
- CAB3260
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-HHIP Antibody |
| Antibody SKU: | CAB3260 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 400-700 of human HHIP (NP_071920.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:1000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Jurkat, HepG2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 400-700 of human HHIP (NP_071920.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | DMCN VPYS IPRS NPHF NSTN QPPE VFAH GLHD PGRC AVDR HPTD ININ LTIL CSDS NGKN RSSA RILQ IIKG KDYE SEPS LLEF KPFS NGPL VGGF VYRG CQSE RLYG SYVF GDRN GNFL TLQQ SPVT KQWQ EKPL CLGT SGSC RGYF SGHI LGFG EDEL GEVY ILSS SKSM TQTH NGKL YKIV DPKR PLMP EECR ATVQ PAQT LTSE CSRL CRNG YCTP TGKC CCSP GWEG DFCR TAKC EPAC RHGG VCVR PNKC LCKK GYLG PQCE QVDR NIRR VTRA GILD QIID MTSY LLDL TSYI V |
| Gene ID: | 64399 |
| Uniprot: | Q96QV1 |
| Cellular Location: | Cell membrane, Cytoplasm, Peripheral membrane protein, Secreted |
| Calculated MW: | 36kDa/78kDa |
| Observed MW: | 79kDa |
| Synonyms: | HHIP, HIP |
| Background: | This gene encodes a member of the hedgehog-interacting protein (HHIP) family. The hedgehog (HH) proteins are evolutionarily conserved protein, which are important morphogens for a wide range of developmental processes, including anteroposterior patterns of limbs and regulation of left-right asymmetry in embryonic development. Multiple cell-surface receptors are responsible for transducing and/or regulating HH signals. The HHIP encoded by this gene is a highly conserved, vertebrate-specific inhibitor of HH signaling. It interacts with all three HH family members, SHH, IHH and DHH. Two single nucleotide polymorphisms (SNPs) near this gene are significantly associated with risk of chronic obstructive pulmonary disease (COPD). A single nucleotide polymorphism in this gene is also strongly associated with human height. |
| UniProt Protein Function: | HHIP: Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family. Belongs to the HHIP family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cell development/differentiation Chromosomal Location of Human Ortholog: 4q28-q32 Cellular Component: cell surface; integral to plasma membrane; cytoplasm; extracellular region Molecular Function:protein binding; oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor; zinc ion binding; quinone binding Biological Process: smoothened signaling pathway; dorsal/ventral pattern formation; skeletal morphogenesis; negative regulation of smoothened signaling pathway; carbohydrate metabolic process; neuroblast proliferation; regulation of fibroblast growth factor receptor signaling pathway; negative regulation of signal transduction |
| NCBI Summary: | This gene encodes a member of the hedgehog-interacting protein (HHIP) family. The hedgehog (HH) proteins are evolutionarily conserved protein, which are important morphogens for a wide range of developmental processes, including anteroposterior patterns of limbs and regulation of left-right asymmetry in embryonic development. Multiple cell-surface receptors are responsible for transducing and/or regulating HH signals. The HHIP encoded by this gene is a highly conserved, vertebrate-specific inhibitor of HH signaling. It interacts with all three HH family members, SHH, IHH and DHH. Two single nucleotide polymorphisms (SNPs) near this gene are significantly associated with risk of chronic obstructive pulmonary disease (COPD). A single nucleotide polymorphism in this gene is also strongly associated with human height.[provided by RefSeq, Feb 2011] |
| UniProt Code: | Q96QV1 |
| NCBI GenInfo Identifier: | 118572655 |
| NCBI Gene ID: | 64399 |
| NCBI Accession: | Q96QV1.3 |
| UniProt Secondary Accession: | Q96QV1,Q6PK09, Q8NCI7, Q9BXK3, Q9H1J4, Q9H7E7, |
| UniProt Related Accession: | Q96QV1 |
| Molecular Weight: | 700 |
| NCBI Full Name: | Hedgehog-interacting protein |
| NCBI Synonym Full Names: | hedgehog interacting protein |
| NCBI Official Symbol: | HHIP |
| NCBI Official Synonym Symbols: | HIP |
| NCBI Protein Information: | hedgehog-interacting protein |
| UniProt Protein Name: | Hedgehog-interacting protein |
| Protein Family: | HHIP-like protein |
| UniProt Gene Name: | HHIP |
| UniProt Entry Name: | HHIP_HUMAN |
 | Western blot analysis of extracts of various cell line, using HHIP antibody (CAB3260) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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