Cell Biology Antibodies 1

Anti-HGFAC Antibody (CAB10114)

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SKU:
CAB10114
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-HGFAC Antibody
Antibody SKU:CAB10114
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 408-655 of human HGFAC (NP_001519.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:LO2, BT-474, SW620, Mouse liver, Mouse pancreas, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 408-655 of human HGFAC (NP_001519.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:IIGG SSSL PGSH PWLA AIYI GDSF CAGS LVHT CWVV SAAH CFSH SPPR DSVS VVLG QHFF NRTT DVTQ TFGI EKYI PYTL YSVF NPSD HDLV LIRL KKKG DRCA TRSQ FVQP ICLP EPGS TFPA GHKC QIAG WGHL DENV SGYS SSLR EALV PLVA DHKC SSPE VYGA DISP NMLC AGYF DCKS DACQ GDSG GPLA CEKN GVAY LYGI ISWG DGCG RLHK PGVY TRVA NYVD WIND RIRP PRRL VAPS
Gene ID:3083
Uniprot:Q04756
Cellular Location:Secreted
Calculated MW:70kDa
Observed MW:75kDa
Synonyms:HGFAC, HGFA
Background:This gene encodes a member of the peptidase S1 protein family. The encoded protein is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:HGFAC: Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form. Belongs to the peptidase S1 family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; EC 3.4.21.-; Secreted; Protease

Chromosomal Location of Human Ortholog: 4p16

Cellular Component: extracellular region; extracellular space

Molecular Function:serine-type endopeptidase activity; serine-type peptidase activity

Biological Process: proteolysis

NCBI Summary:This gene encodes a member of the peptidase S1 protein family. The encoded protein is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
UniProt Code:Q04756
NCBI GenInfo Identifier:547643
NCBI Gene ID:3083
NCBI Accession:Q04756.1
UniProt Secondary Accession:Q04756,Q14726, Q2M1W7, Q53X47,
UniProt Related Accession:Q04756
Molecular Weight:70,682 Da
NCBI Full Name:Hepatocyte growth factor activator
NCBI Synonym Full Names:HGF activator
NCBI Official Symbol:HGFAC  
NCBI Official Synonym Symbols:HGFA  
NCBI Protein Information:hepatocyte growth factor activator
UniProt Protein Name:Hepatocyte growth factor activator
Protein Family:Hepatocyte growth factor activator
UniProt Gene Name:HGFAC  
UniProt Entry Name:HGFA_HUMAN
Anti-HGFAC Antibody (CAB10114)Western blot analysis of extracts of various cell lines, using HGFAC antibody (CAB10114) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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