Cell Biology Antibodies 13
Anti-HEYL Antibody (CAB17683)
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- SKU:
- CAB17683
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-HEYL Antibody |
| Antibody SKU: | CAB17683 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 129-328 of human HEYL (NP_055386.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | A-549, BxPC-3 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 129-328 of human HEYL (NP_055386.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | IRYL GVLE GPSS RADP VRIR LLSH LNSY AAEM EPSP TPTG PLAF PAWP WSFF HSCP GLPA LSNQ LAIL GRVP SPVL PGVS SPAY PIPA LRTA PLRR ATGI ILPA RRNV LPSR GASS TRRA RPLE RPAT PVPV APSS RAAR SSHI APLL QSSS PTPP GPTG SAAY VAVP TPNS SSPG PAGR PAGA MLYH SWVS EITE IGAF |
| Gene ID: | 26508 |
| Uniprot: | Q9NQ87 |
| Cellular Location: | |
| Calculated MW: | 328kDa |
| Observed MW: | 35kDa |
 | Western blot - HEYL Polyclonal Antibody (CAB17683) |
| Synonyms: | HEY3, HRT3, HESR3, bHLHb33, HEYL |
| Background: | This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. |
| UniProt Protein Function: | HEYL: Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. Belongs to the HEY family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 1p34.3 Cellular Component: cytoplasm; nucleoplasm; nucleus Molecular Function:AF-1 domain binding; protein binding; protein heterodimerization activity; transcription corepressor activity; transcription factor activity Biological Process: mesenchymal cell development; negative regulation of transcription, DNA-dependent; Notch signaling pathway; positive regulation of neuron differentiation; positive regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NQ87 |
| NCBI GenInfo Identifier: | 146286205 |
| NCBI Gene ID: | 26508 |
| NCBI Accession: | Q9NQ87.2 |
| UniProt Secondary Accession: | Q9NQ87,Q5TG99, |
| UniProt Related Accession: | Q9NQ87 |
| Molecular Weight: | 35,087 Da |
| NCBI Full Name: | Hairy/enhancer-of-split related with YRPW motif-like protein |
| NCBI Synonym Full Names: | hes related family bHLH transcription factor with YRPW motif-like |
| NCBI Official Symbol: | HEYL |
| NCBI Official Synonym Symbols: | HEY3; HRT3; HESR3; bHLHb33 |
| NCBI Protein Information: | hairy/enhancer-of-split related with YRPW motif-like protein |
| UniProt Protein Name: | Hairy/enhancer-of-split related with YRPW motif-like protein |
| UniProt Synonym Protein Names: | Class B basic helix-loop-helix protein 33; bHLHb33; Hairy-related transcription factor 3; HRT-3; hHRT3 |
| Protein Family: | Hairy/enhancer-of-split related with YRPW motif-like protein |
| UniProt Gene Name: | HEYL |
| UniProt Entry Name: | HEYL_HUMAN |
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