| UniProt Protein Function: | HHEX: Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL.Protein type: Transcription factor; DNA-bindingChromosomal Location of Human Ortholog: 10q23.33Cellular Component: cytoplasm; nucleusMolecular Function: DNA bending activity; eukaryotic initiation factor 4E binding; protein binding; protein homodimerization activity; sequence-specific DNA binding; TATA-binding protein binding; transcription factor bindingBiological Process: anterior/posterior pattern formation; B cell differentiation; cell differentiation; cell proliferation; mRNA export from nucleus; negative regulation of angiogenesis; negative regulation of cyclin-dependent protein kinase activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of vascular endothelial growth factor receptor signaling pathway; poly(A)+ mRNA export from nucleus; positive regulation of transcription from RNA polymerase II promoter; positive regulation of Wnt receptor signaling pathway |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q03014 |
| NCBI GenInfo Identifier: | 547658 |
| NCBI Gene ID: | 3087 |
| NCBI Accession: | Q03014.1 |
| UniProt Secondary Accession: | Q03014,Q96CE9, B1AQ17 |
| UniProt Related Accession: | Q03014 |
| Molecular Weight: | 30,022 Da |
| NCBI Full Name: | Hematopoietically-expressed homeobox protein HHEX |
| NCBI Synonym Full Names: | hematopoietically expressed homeobox |
| NCBI Official Symbol: | HHEX |
| NCBI Official Synonym Symbols: | HEX; PRH; HMPH; PRHX; HOX11L-PEN |
| NCBI Protein Information: | hematopoietically-expressed homeobox protein HHEX |
| UniProt Protein Name: | Hematopoietically-expressed homeobox protein HHEX |
| UniProt Synonym Protein Names: | Homeobox protein PRH |
| Protein Family: | Hematopoietically-expressed homeobox protein |
| UniProt Gene Name: | HHEX |
| UniProt Entry Name: | HHEX_HUMAN |
