ChIP Antibodies

Anti-HES5 Antibody (CAB17282)

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SKU:
CAB17282
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology

Description

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Antibody Name:Anti-HES5 Antibody
Antibody SKU:CAB17282
Antibody Size:20uL, 50 uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide of human HES5.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:A synthetic peptide of human HES5.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:388585
Uniprot:Q5TA89
Cellular Location:
Calculated MW:18kDa
Observed MW:Refer to figures
Synonyms:HES5, bHLHb38
Background:This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer.
UniProt Protein Function:HES5: Transcriptional repressor of genes that require a bHLH protein for their transcription.
UniProt Protein Details:

Protein type:Transcription regulation; Cell development/differentiation

Chromosomal Location of Human Ortholog: 1p36.32

Cellular Component: nucleoplasm

Biological Process: astrocyte differentiation; auditory receptor cell differentiation; brain development; camera-type eye development; cartilage development; cell adhesion; cell maturation; chondrocyte differentiation; glial cell fate commitment; myelination in the central nervous system; negative regulation of astrocyte differentiation; negative regulation of neuron differentiation; negative regulation of oligodendrocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; neural tube development; Notch signaling pathway; oligodendrocyte development; positive regulation of BMP signaling pathway; positive regulation of cell proliferation; positive regulation of JAK-STAT cascade; positive regulation of smooth muscle cell proliferation; positive regulation of transcription, DNA-dependent; positive regulation of tyrosine phosphorylation of Stat3 protein; protein complex assembly; regulation of cell differentiation; regulation of myelination; regulation of neurogenesis; smoothened signaling pathway; telencephalon development

NCBI Summary:This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer. [provided by RefSeq, Dec 2008]
UniProt Code:Q5TA89
NCBI GenInfo Identifier:74745795
NCBI Gene ID:388585
NCBI Accession:Q5TA89.1
UniProt Secondary Accession:Q5TA89,B9DI85,
UniProt Related Accession:Q5TA89
Molecular Weight:18,226 Da
NCBI Full Name:Transcription factor HES-5
NCBI Synonym Full Names:hes family bHLH transcription factor 5
NCBI Official Symbol:HES5  
NCBI Official Synonym Symbols:bHLHb38  
NCBI Protein Information:transcription factor HES-5
UniProt Protein Name:Transcription factor HES-5
UniProt Synonym Protein Names:Class B basic helix-loop-helix protein 38; bHLHb38; Hairy and enhancer of split 5
Protein Family:Transcription factor
UniProt Gene Name:HES5  
UniProt Entry Name:HES5_HUMAN
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