Developmental Biology
Anti-HES5 Antibody (CAB16237)
- SKU:
- CAB16237
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-HES5 Antibody |
| Antibody SKU: | CAB16237 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic Peptide of human HES5 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse brain |
| Immunogen: | A synthetic Peptide of human HES5 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 388585 |
| Uniprot: | Q5TA89 |
| Cellular Location: | Nucleus |
| Calculated MW: | 18kDa |
| Observed MW: | 18kDa |
| Synonyms: | HES5, bHLHb38 |
| Background: | This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer. |
| UniProt Protein Function: | HES5: Transcriptional repressor of genes that require a bHLH protein for their transcription. |
| UniProt Protein Details: | Protein type:Transcription regulation; Cell development/differentiation Chromosomal Location of Human Ortholog: 1p36.32 Cellular Component: nucleoplasm Biological Process: astrocyte differentiation; auditory receptor cell differentiation; brain development; camera-type eye development; cartilage development; cell adhesion; cell maturation; chondrocyte differentiation; glial cell fate commitment; myelination in the central nervous system; negative regulation of astrocyte differentiation; negative regulation of neuron differentiation; negative regulation of oligodendrocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; neural tube development; Notch signaling pathway; oligodendrocyte development; positive regulation of BMP signaling pathway; positive regulation of cell proliferation; positive regulation of JAK-STAT cascade; positive regulation of smooth muscle cell proliferation; positive regulation of transcription, DNA-dependent; positive regulation of tyrosine phosphorylation of Stat3 protein; protein complex assembly; regulation of cell differentiation; regulation of myelination; regulation of neurogenesis; smoothened signaling pathway; telencephalon development |
| NCBI Summary: | This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer. [provided by RefSeq, Dec 2008] |
| UniProt Code: | Q5TA89 |
| NCBI GenInfo Identifier: | 74745795 |
| NCBI Gene ID: | 388585 |
| NCBI Accession: | Q5TA89.1 |
| UniProt Secondary Accession: | Q5TA89,B9DI85, |
| UniProt Related Accession: | Q5TA89 |
| Molecular Weight: | 18,226 Da |
| NCBI Full Name: | Transcription factor HES-5 |
| NCBI Synonym Full Names: | hes family bHLH transcription factor 5 |
| NCBI Official Symbol: | HES5 |
| NCBI Official Synonym Symbols: | bHLHb38 |
| NCBI Protein Information: | transcription factor HES-5 |
| UniProt Protein Name: | Transcription factor HES-5 |
| UniProt Synonym Protein Names: | Class B basic helix-loop-helix protein 38; bHLHb38; Hairy and enhancer of split 5 |
| Protein Family: | Transcription factor |
| UniProt Gene Name: | HES5 |
| UniProt Entry Name: | HES5_HUMAN |
 | Western blot analysis of extracts of mouse brain, using HES5 antibody (CAB16237) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5min. |
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