Epigenetics & Nuclear Signaling Antibodies 5
Anti-Hes1 Antibody (CAB0925)
- SKU:
- CAB0925
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-Hes1 Antibody |
| Antibody SKU: | CAB0925 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Hes1 |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse eye, Rat testis |
| Immunogen: | A synthesized peptide derived from human Hes1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3280 |
| Uniprot: | Q14469 |
| Cellular Location: | |
| Calculated MW: | 30kDa |
| Observed MW: | 30KDa |
 | Western blot - Hes1 Rabbit mAb (CAB0925) |
| Synonyms: | HES-1, HHL, HRY, bHLHb39 |
| Background: | This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | HES1: Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Transcription factor; Cell development/differentiation Chromosomal Location of Human Ortholog: 3q28-q29 Cellular Component: nucleoplasm; nucleus Molecular Function:DNA binding; histone deacetylase binding; protein binding; protein homodimerization activity; sequence-specific DNA binding; transcription factor activity Biological Process: artery morphogenesis; negative regulation of oligodendrocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nervous system development; Notch signaling pathway; positive regulation of astrocyte differentiation; positive regulation of cell proliferation; positive regulation of DNA binding; positive regulation of JAK-STAT cascade; positive regulation of mitotic cell cycle, embryonic; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tyrosine phosphorylation of Stat3 protein; protein complex assembly; radial glial cell differentiation in the forebrain; STAT protein nuclear translocation; thymus development |
| NCBI Summary: | This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14469 |
| NCBI GenInfo Identifier: | 3913825 |
| NCBI Gene ID: | 3280 |
| NCBI Accession: | Q14469.1 |
| UniProt Secondary Accession: | Q14469,Q6FHB2, |
| UniProt Related Accession: | Q14469 |
| Molecular Weight: | 29,541 Da |
| NCBI Full Name: | Transcription factor HES-1 |
| NCBI Synonym Full Names: | hes family bHLH transcription factor 1 |
| NCBI Official Symbol: | HES1 |
| NCBI Official Synonym Symbols: | HHL; HRY; HES-1; bHLHb39 |
| NCBI Protein Information: | transcription factor HES-1 |
| UniProt Protein Name: | Transcription factor HES-1 |
| UniProt Synonym Protein Names: | Class B basic helix-loop-helix protein 39; bHLHb39; Hairy and enhancer of split 1; Hairy homolog; Hairy-like protein; hHL |
| Protein Family: | Protein |
| UniProt Gene Name: | HES1 |
| UniProt Entry Name: | HES1_HUMAN |
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