Cell Biology Antibodies 15
Anti-HERC6 Antibody (CAB18634)
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- SKU:
- CAB18634
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-HERC6 Antibody |
| Antibody SKU: | CAB18634 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human HERC6. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant protein of human HERC6. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 55008 |
| Uniprot: | Q8IVU3 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | |
| Background: |
| UniProt Protein Function: | HERC6: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system; Ligase; EC 6.3.2.- Chromosomal Location of Human Ortholog: 4q22.1 Cellular Component: cytoplasm; cytosol; nucleus Molecular Function:ligase activity; ubiquitin-protein ligase activity Biological Process: hemopoietic progenitor cell differentiation; protein ubiquitination during ubiquitin-dependent protein catabolic process |
| NCBI Summary: | HERC6 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q8IVU3 |
| NCBI GenInfo Identifier: | 259089405 |
| NCBI Gene ID: | 55008 |
| NCBI Accession: | NP_001158608.1 |
| UniProt Secondary Accession: | Q8IVU3,Q5GC90, Q5GRH3, Q5HYM6, Q5JPB6, Q6PIF4, Q8NAN3 Q9NWS4, B4DIY5, |
| UniProt Related Accession: | Q8IVU3 |
| Molecular Weight: | 32,717 Da |
| NCBI Full Name: | probable E3 ubiquitin-protein ligase HERC6 isoform 2 |
| NCBI Synonym Full Names: | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 |
| NCBI Official Symbol: | HERC6 |
| NCBI Protein Information: | probable E3 ubiquitin-protein ligase HERC6 |
| UniProt Protein Name: | Probable E3 ubiquitin-protein ligase HERC6 |
| UniProt Synonym Protein Names: | HECT domain and RCC1-like domain-containing protein 6 |
| Protein Family: | E3 ISG15--protein ligase |
| UniProt Gene Name: | HERC6 |
| UniProt Entry Name: | HERC6_HUMAN |
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