Cell Biology Antibodies 6
Anti-Hepcidin Antibody (CAB1601)
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- SKU:
- CAB1601
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Hepcidin Antibody |
| Antibody SKU: | CAB1601 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-84 of human Hepcidin (NP_066998.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | MDA-MB-435 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-84 of human Hepcidin (NP_066998.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MALS SQIW AACL LLLL LLAS LTSG SVFP QQTG QLAE LQPQ DRAG ARAS WMPM FQRR RRRD THFP ICIF CCGC CHRS KCGM CCKT |
| Gene ID: | 57817 |
| Uniprot: | P81172 |
| Cellular Location: | Secreted |
| Calculated MW: | 9kDa |
| Observed MW: | 10kDa |
| Synonyms: | HAMP, HEPC, HFE2B, LEAP1, PLTR, hepcidin |
| Background: | The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity against bacteria and fungi. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. |
| UniProt Protein Function: | HAMP: Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. Defects in HAMP are the cause of hemochromatosis type 2B (HFE2B); also known as juvenile hemochromatosis (JH). HFE2B is a disorder of iron metabolism with excess deposition of iron in the tissues, bronze skin pigmentation, hepatic cirrhosis, arthropathy and diabetes. The most common symptoms of hemochromatosis type 2 at presentation are hypogonadism and cardiomyopathy. Belongs to the hepcidin family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 19q13.1 Cellular Component: apical cortex; extracellular region Molecular Function:hormone activity Biological Process: killing of cells of another organism; cellular iron ion homeostasis; defense response to bacterium; immune response; defense response to fungus Disease: Hemochromatosis, Type 2b |
| NCBI Summary: | The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity against bacteria and fungi. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Oct 2014] |
| UniProt Code: | P81172 |
| NCBI GenInfo Identifier: | 10720397 |
| NCBI Gene ID: | 57817 |
| NCBI Accession: | P81172.2 |
| UniProt Related Accession: | P81172 |
| Molecular Weight: | |
| NCBI Full Name: | Hepcidin |
| NCBI Synonym Full Names: | hepcidin antimicrobial peptide |
| NCBI Official Symbol: | HAMP |
| NCBI Official Synonym Symbols: | HEPC; PLTR; HFE2B; LEAP1 |
| NCBI Protein Information: | hepcidin |
| UniProt Protein Name: | Hepcidin |
| UniProt Synonym Protein Names: | Liver-expressed antimicrobial peptide 1; LEAP-1; Putative liver tumor regressor |
| Protein Family: | Hepcidin |
| UniProt Gene Name: | HAMP |
| UniProt Entry Name: | HEPC_HUMAN |
 | Western blot analysis of extracts of MDA-MB-435 cells, using Hepcidin antibody (CAB1601). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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