Cell Cycle Antibodies 2

Anti-HEC1 Antibody (CAB2392)

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SKU:
CAB2392
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Cycle

Description

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Antibody Name:Anti-HEC1 Antibody
Antibody SKU:CAB2392
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human HEC1
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HeLa, Jurkat
Immunogen:A synthesized peptide derived from human HEC1
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10403
Uniprot:O14777
Cellular Location:
Calculated MW:74kDa
Observed MW:76KDa
Synonyms:HEC, HEC1, HsHec1, KNTC2, TID3, hsNDC80
Background:This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011]
UniProt Protein Function:HEC1: plays an essential role in chromosome segregation by interacting through its coiled-coil domains with several proteins that modulate the G2/M phase. Phosphorylation by Nek2 is essential for faithful chromosome segregation. Required for the recruitment of Mps1 kinase and Mad1/Mad2 complexes to kinetochores.
UniProt Protein Details:

Protein type:Cell cycle regulation

Chromosomal Location of Human Ortholog: 18p11.32

Cellular Component: chromosome, pericentric region; cytosol; kinetochore; membrane; nucleus

Molecular Function:identical protein binding; protein binding; structural constituent of cytoskeleton

Biological Process: attachment of spindle microtubules to kinetochore; attachment of spindle microtubules to kinetochore during mitosis; chromosome segregation; establishment of mitotic spindle orientation; mitosis; mitotic sister chromatid segregation; mitotic spindle organization and biogenesis; sister chromatid cohesion

NCBI Summary:This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011]
UniProt Code:O14777
NCBI GenInfo Identifier:74735330
NCBI Gene ID:10403
NCBI Accession:O14777.1
UniProt Secondary Accession:O14777,Q6PJX2,
UniProt Related Accession:O14777
Molecular Weight:73,913 Da
NCBI Full Name:Kinetochore protein NDC80 homolog
NCBI Synonym Full Names:NDC80, kinetochore complex component
NCBI Official Symbol:NDC80  
NCBI Official Synonym Symbols:HEC; HEC1; TID3; KNTC2; HsHec1; hsNDC80  
NCBI Protein Information:kinetochore protein NDC80 homolog
UniProt Protein Name:Kinetochore protein NDC80 homolog
UniProt Synonym Protein Names:Highly expressed in cancer protein; Kinetochore protein Hec1; HsHec1; Kinetochore-associated protein 2; Retinoblastoma-associated protein HEC
Protein Family:Kinetochore protein
UniProt Gene Name:NDC80  
UniProt Entry Name:NDC80_HUMAN
Anti-HEC1 Antibody (CAB2392)Western blot - HEC1 Rabbit mAb (CAB2392)
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