Cell Cycle Antibodies 2
Anti-HEC1 Antibody (CAB2392)
- SKU:
- CAB2392
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Description
| Antibody Name: | Anti-HEC1 Antibody |
| Antibody SKU: | CAB2392 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human HEC1 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HeLa, Jurkat |
| Immunogen: | A synthesized peptide derived from human HEC1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 10403 |
| Uniprot: | O14777 |
| Cellular Location: | |
| Calculated MW: | 74kDa |
| Observed MW: | 76KDa |
| Synonyms: | HEC, HEC1, HsHec1, KNTC2, TID3, hsNDC80 |
| Background: | This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011] |
| UniProt Protein Function: | HEC1: plays an essential role in chromosome segregation by interacting through its coiled-coil domains with several proteins that modulate the G2/M phase. Phosphorylation by Nek2 is essential for faithful chromosome segregation. Required for the recruitment of Mps1 kinase and Mad1/Mad2 complexes to kinetochores. |
| UniProt Protein Details: | Protein type:Cell cycle regulation Chromosomal Location of Human Ortholog: 18p11.32 Cellular Component: chromosome, pericentric region; cytosol; kinetochore; membrane; nucleus Molecular Function:identical protein binding; protein binding; structural constituent of cytoskeleton Biological Process: attachment of spindle microtubules to kinetochore; attachment of spindle microtubules to kinetochore during mitosis; chromosome segregation; establishment of mitotic spindle orientation; mitosis; mitotic sister chromatid segregation; mitotic spindle organization and biogenesis; sister chromatid cohesion |
| NCBI Summary: | This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011] |
| UniProt Code: | O14777 |
| NCBI GenInfo Identifier: | 74735330 |
| NCBI Gene ID: | 10403 |
| NCBI Accession: | O14777.1 |
| UniProt Secondary Accession: | O14777,Q6PJX2, |
| UniProt Related Accession: | O14777 |
| Molecular Weight: | 73,913 Da |
| NCBI Full Name: | Kinetochore protein NDC80 homolog |
| NCBI Synonym Full Names: | NDC80, kinetochore complex component |
| NCBI Official Symbol: | NDC80 |
| NCBI Official Synonym Symbols: | HEC; HEC1; TID3; KNTC2; HsHec1; hsNDC80 |
| NCBI Protein Information: | kinetochore protein NDC80 homolog |
| UniProt Protein Name: | Kinetochore protein NDC80 homolog |
| UniProt Synonym Protein Names: | Highly expressed in cancer protein; Kinetochore protein Hec1; HsHec1; Kinetochore-associated protein 2; Retinoblastoma-associated protein HEC |
| Protein Family: | Kinetochore protein |
| UniProt Gene Name: | NDC80 |
| UniProt Entry Name: | NDC80_HUMAN |
 | Western blot - HEC1 Rabbit mAb (CAB2392) |
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